Sodium tanshinone iia sulfonate protects mice from cona-induced hepatitis via inhibiting nf-kappa b and ifn-gamma/stat1 pathways
文献类型：期刊论文
| 作者 | Xu, Yan1,3; Feng, Dechun1,3; Wang, Ying2; Lin, Shuting2; Xu, Lingyun1,2 |
| 刊名 | Journal of clinical immunology
 |
| 出版日期 | 2008-09-01 |
| 卷号 | 28期号:5页码:512-519 |
| 关键词 | Sodium tanshinone iia sulfonate Concanavalin a-induced hepatitis Nf-kappa b Stat1 |
| ISSN号 | 0271-9142 |
| DOI | 10.1007/s10875-008-9206-3 |
| 通讯作者 | Xu, lingyun(lyxu@sibs.ac.cn) |
| 英文摘要 | Introduction sodium tanshinone iia sulfonate (sts) is a water-soluble derivative of tanshinone iia, the main pharmacologically active component of salvia miltiorrhiza. the aim of this study was to investigate the effect of sts on concanavalin a (cona)-induced hepatitis (cih) in mice, an experimental model of immune-mediated liver injury. results c57bl/6 mice pretreated with sts released much less alanine transaminase into plasma in response to cona challenge and had reduced inflammatory infiltration and hepatocyte apoptosis in the liver compared with control mice pretreated with vehicle solutions. thus, sts protected mice from cih. in sts-pretreated mice induced with cih, we found abrogated tumor necrosis factor-alpha and interferon (ifn)-gamma production. moreover, mrna expressions of ifn-inducible protein-10 and macrophage inflammatory protein-1 alpha in these mice were decreased. the mechanism of anti-inflammatory effects of sts may be attributed to its modulation of crucial inflammatory signaling pathways, including nf-kappa b and ifn-gamma/stat1. conclusion in conclusion, sts was capable of protecting mice from immune-mediated liver injury in vivo, and the protection was associated with its suppressive effect on the production of important inflammatory mediators through modulating nf-kappa b and ifn-gamma/stat1 signaling pathways. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; CELL-MEDIATED HEPATITIS ; REGULATORY FACTOR-I ; A-INDUCED HEPATITIS ; CONCANAVALIN-A ; LIVER-INJURY ; INTRACELLULAR PATHWAYS ; INTERFERON-GAMMA ; IFN-GAMMA ; ACTIVATION |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000259007000014 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2393262 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Lingyun |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Univ, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yan,Feng, Dechun,Wang, Ying,et al. Sodium tanshinone iia sulfonate protects mice from cona-induced hepatitis via inhibiting nf-kappa b and ifn-gamma/stat1 pathways[J]. Journal of clinical immunology,2008,28(5):512-519. |
| APA | Xu, Yan,Feng, Dechun,Wang, Ying,Lin, Shuting,&Xu, Lingyun.(2008).Sodium tanshinone iia sulfonate protects mice from cona-induced hepatitis via inhibiting nf-kappa b and ifn-gamma/stat1 pathways.Journal of clinical immunology,28(5),512-519. |
| MLA | Xu, Yan,et al."Sodium tanshinone iia sulfonate protects mice from cona-induced hepatitis via inhibiting nf-kappa b and ifn-gamma/stat1 pathways".Journal of clinical immunology 28.5(2008):512-519. |
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来源：中国科学院大学
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