Studies on the biotransformation of aconitine in human intestinal bacteria using soft-ionization mass spectrometry
文献类型：期刊论文
| 作者 | Zhao Yu-Feng1,2; Song Feng-Rui1; Guo Xin-Hua1; Liu Shu-Ying1 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2008-01-10 |
| 卷号 | 29期号:1页码:55-59 |
| 关键词 | Aconitine Human intestinal bacteria Biotransformation Electrospray ionization mass spectrometry |
| ISSN号 | 0251-0790 |
| 通讯作者 | Liu shu-ying(syliu19@yahoo.com.cn) |
| 英文摘要 | To study the biotransformation of aconitine in human intestine, aconitine was incubated with human intestinal bacteria in vitro. aconitine and its metabolites formed the protonated molecule [ m + h](+) in positive ion mode. according to the m/z of [ m + h] (+), the metabolites of aconitine were investigated by electrospray ionization tandem mass spectrometry directly. aconitine can be transformed by human intestinal bacteria. aconitine was converted into more than twenty kinds of new metabolites such as mono-ester aconitum alkaloids, diester aconitines and lipo-alkaloids by deacetylation, dehydroxylation, demethylation and esterification. |
| WOS关键词 | ALKALOIDS ; CARMIECHAELI ; URINE ; SERUM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000252618000011 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2393435 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu Shu-Ying |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrum, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Yu-Feng,Song Feng-Rui,Guo Xin-Hua,et al. Studies on the biotransformation of aconitine in human intestinal bacteria using soft-ionization mass spectrometry[J]. Chemical journal of chinese universities-chinese,2008,29(1):55-59. |
| APA | Zhao Yu-Feng,Song Feng-Rui,Guo Xin-Hua,&Liu Shu-Ying.(2008).Studies on the biotransformation of aconitine in human intestinal bacteria using soft-ionization mass spectrometry.Chemical journal of chinese universities-chinese,29(1),55-59. |
| MLA | Zhao Yu-Feng,et al."Studies on the biotransformation of aconitine in human intestinal bacteria using soft-ionization mass spectrometry".Chemical journal of chinese universities-chinese 29.1(2008):55-59. |
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来源：中国科学院大学
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