M-peis nanogels: potential nonviral vector for systemic plasmid delivery to tumor cells
文献类型：期刊论文
| 作者 | Dong, L.1,2,3,4; Xu, H.1,2,5,6; Liu, Y-B7; Lu, B.1,2; Xu, D-M3; Li, B-H1,2,5,6; Gao, J.1,2,5,6; Wu, M.1,2; Yao, S-D1,3; Zhao, J.1,2,5,6 |
| 刊名 | Cancer gene therapy
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 16期号:7页码:561-566 |
| 关键词 | Gene delivery Nonviral vectors Polyethylenimine Nanogels Systemic delivery |
| ISSN号 | 0929-1903 |
| DOI | 10.1038/cgt.2009.11 |
| 通讯作者 | Yao, s-d(yaoside@sinap.ac.cn) |
| 英文摘要 | Successfully systemic gene therapy has been hindered by vector-related limitations, including toxicity and inefficient gene delivery to tumor cells after intravenous administration. in this study, we evaluated the potential of spherical polyethylenimine nanogels (m-peis) as a novel vector for intravenous delivery of plasmids to tumor cells. m-peis provided a sustained release of plasmids up to 14 days and were also effective in protecting plasmids from enzymatic degradation in serum-conditioned media. m-peis showed no obvious cytotoxicity to mammalian cells in vitro as well as to liver, heart and kidney in mice after intravenous injection. importantly, following intravenous administration of m-peis/plasmid complexes into human hepatocellular carcinoma xenograft-bearing mice, green fluorescence protein reporter gene expression was predominantly found in the tumor. this study indicates that m-peis may be a candidate for systemic delivery of plasmids into tumors. cancer gene therapy (2009) 16, 561-566; doi:10.1038/cgt.2009.11; published online 30 january 2009 |
| WOS关键词 | GENE DELIVERY ; IN-VIVO ; LINEAR POLYETHYLENIMINE ; POLYMERIC NANOPARTICLES ; DNA COMPLEXES ; EXPRESSION ; INJECTION ; MICE |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine |
| WOS类目 | Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000267039000003 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394077 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yao, S-D |
| 作者单位 | 1.Second Mil Med Univ, Int Joint Canc Inst, Shanghai 200433, Peoples R China 2.Second Mil Med Univ, Eastern Hosp Hepatobiliary Surg, Shanghai 200433, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Chinese Natl Engn Res Ctr Antibody Med, Shanghai, Peoples R China 6.Shanghai Key Lab Cell Engn, Shanghai, Peoples R China 7.Nanjing Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, L.,Xu, H.,Liu, Y-B,et al. M-peis nanogels: potential nonviral vector for systemic plasmid delivery to tumor cells[J]. Cancer gene therapy,2009,16(7):561-566. |
| APA | Dong, L..,Xu, H..,Liu, Y-B.,Lu, B..,Xu, D-M.,...&Guo, Y-J.(2009).M-peis nanogels: potential nonviral vector for systemic plasmid delivery to tumor cells.Cancer gene therapy,16(7),561-566. |
| MLA | Dong, L.,et al."M-peis nanogels: potential nonviral vector for systemic plasmid delivery to tumor cells".Cancer gene therapy 16.7(2009):561-566. |
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来源：中国科学院大学
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