Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese
文献类型：期刊论文
| 作者 | Lan, Jie1; Song, Manshu2; Pan, Chunhui1; Zhuang, Guoqing1; Wang, Youxin2; Ma, Wenzhan1; Chu, Qiaoyun1; Lai, Qingxuan1; Xu, Feng1; Li, Yanli1 |
| 刊名 | Journal of human genetics
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 54期号:8页码:457-460 |
| 关键词 | Case-control study Dopamine d2 receptor Dopamine transporter Disorder of fluent speech Han chinese Snps |
| ISSN号 | 1434-5161 |
| DOI | 10.1038/jhg.2009.60 |
| 通讯作者 | Wang, wei(wei6014@yahoo.com) |
| 英文摘要 | Normal function of the dopaminergic system is necessary for speech fluency. there was evidence that the activities of dopamine transporter (dat) and dopamine d2 receptor (drd2) could be altered in people with speech disfluency. this study aims to ascertain the possible correlation between two dopaminergic genes (slc6a3 and drd2) and disorder of speech fluency, and to determine the allelic frequencies of the five single-nucleotide polymorphisms (snps) (rs2617604, rs28364997, rs28364998 in slc6a3 and rs6275, rs6277 in drd2) among han chinese patients with this disorder. a sample of 112 patients with speech disfluency and 112 gender-matched controls were included in this case-control study. the results show that the presence of c allele at rs6277 in drd2 gene is associated with increased susceptibility to the disorder, whereas t allele is protective. haplotype 939t/957t is also a protective factor. journal of human genetics (2009) 54, 457-460; doi: 10.1038/jhg.2009.60; published online 10 july 2009 |
| WOS关键词 | ATTENTION-DEFICIT HYPERACTIVITY ; C957T POLYMORPHISM ; RISPERIDONE ; DISORDER ; FLUENCY ; SPEECH |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000269939000004 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394336 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Dept Genet, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China 2.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China 3.Curtin Univ Technol, Sch Publ Hlth, Perth, WA, Australia |
| 推荐引用方式 GB/T 7714 | Lan, Jie,Song, Manshu,Pan, Chunhui,et al. Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese[J]. Journal of human genetics,2009,54(8):457-460. |
| APA | Lan, Jie.,Song, Manshu.,Pan, Chunhui.,Zhuang, Guoqing.,Wang, Youxin.,...&Wang, Wei.(2009).Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese.Journal of human genetics,54(8),457-460. |
| MLA | Lan, Jie,et al."Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese".Journal of human genetics 54.8(2009):457-460. |
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来源：中国科学院大学
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