Alternative translation of oct4 by an internal ribosome entry site and its novel function in stress response
文献类型：期刊论文
| 作者 | Wang, Xia1,2; Zhao, Yannan1; Xiao, Zhifeng1; Chen, Bing1; Wei, Zhanliang1; Wang, Bin1; Zhang, Jing1; Han, Jin1; Gao, Yuan1; Li, Lingsong3 |
| 刊名 | Stem cells
 |
| 出版日期 | 2009 |
| 卷号 | 27期号:6页码:1265-1275 |
| 关键词 | Oct4 Alternative translation initiation Internal ribosome entry site Cell stress Apoptosis Stress granule |
| ISSN号 | 1066-5099 |
| DOI | 10.1002/stem.58 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Oct4 is a pivotal transcription factor in maintaining the pluripotency and self-renewal capacities of embryonic stem (es) cells. human oct4 can generate two isoforms by alternative splicing, termed oct4a and oct4b. oct4a confers the stemness properties of es cells, whereas the function of oct4b is unknown. we present here the diverse protein products and a novel function of oct4 gene. a single oct4b mrna can encode three isoforms by alternative translation initiation at aug and cug start codons, respectively. a putative internal ribosome entry site (ires) has been identified in oct4b mrna accounting for the translation mechanism. the oct4b-190 is upregulated under stress conditions and it may protect cell against apoptosis under stress. this work evokes the significance to distinguish the biological function of the protein products of oct4. the oct4 gene, by the regulation of alternative splicing and alternative translation initiation, may carry out more crucial roles in many biological events. stem cells 2009;27:1265-1275 |
| WOS关键词 | EMBRYONIC STEM-CELLS ; FIBROBLAST-GROWTH-FACTOR ; NON-AUG CODONS ; MESSENGER-RNA ; PREIMPLANTATION EMBRYOS ; MEDIATED TRANSLATION ; NUCLEAR-LOCALIZATION ; SELF-RENEWAL ; C-MYC ; EXPRESSION |
| WOS研究方向 | Cell Biology ; Biotechnology & Applied Microbiology ; Oncology ; Hematology |
| WOS类目 | Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Oncology ; Cell Biology ; Hematology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267056000006 |
| 出版者 | ALPHAMED PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394584 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 3.Peking Univ, Stem Cell Res Ctr, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xia,Zhao, Yannan,Xiao, Zhifeng,et al. Alternative translation of oct4 by an internal ribosome entry site and its novel function in stress response[J]. Stem cells,2009,27(6):1265-1275. |
| APA | Wang, Xia.,Zhao, Yannan.,Xiao, Zhifeng.,Chen, Bing.,Wei, Zhanliang.,...&Dai, Jianwu.(2009).Alternative translation of oct4 by an internal ribosome entry site and its novel function in stress response.Stem cells,27(6),1265-1275. |
| MLA | Wang, Xia,et al."Alternative translation of oct4 by an internal ribosome entry site and its novel function in stress response".Stem cells 27.6(2009):1265-1275. |
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来源：中国科学院大学
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