Modeling the age distribution of gene duplications in vertebrate genome using mixture density
文献类型：期刊论文
| 作者 | Wang, Zhen1,2; Ding, Guohui1,2; Yu, Zhonghao3; Liu, Lei1,4; Li, Yixue1,3,4 |
| 刊名 | Genomics
 |
| 出版日期 | 2009-02-01 |
| 卷号 | 93期号:2页码:146-151 |
| 关键词 | Gene duplication Vertebrate evolution Age distribution Mixture density |
| ISSN号 | 0888-7543 |
| DOI | 10.1016/j.ygeno.2008.10.008 |
| 通讯作者 | Liu, lei(leiliu@sibs.ac.cn) |
| 英文摘要 | Gene duplication is a fundamental source of genetic novelty in vertebrate evolution. in this study, we hypothesized that both continuous small-scale and discrete large-scale duplication play crucial roles in vertebrate genome. on the basis of the hypothesis, we developed mixture density to model the age distribution of gene duplications. the results of formal statistical inference suggest that the contribution of both duplication modes can be confirmed by the model, and one or two successive rounds of large-scale duplication are placed at the early origin of vertebrates. the half life of a duplicate becomes much longer in the long run than in the short run, which implies its functional evolution from redundancy to conservation. in addition, the model reveals disparate impact of the duplication modes, which appears to be correlated with macroevolution. (c) 2008 elsevier inc. all rights reserved |
| WOS关键词 | MOLECULAR CLOCK ; EVOLUTION ; RESOURCE ; FAMILIES ; ROUNDS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000263227600006 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394644 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Lei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Shanghai 200030, Peoples R China 4.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhen,Ding, Guohui,Yu, Zhonghao,et al. Modeling the age distribution of gene duplications in vertebrate genome using mixture density[J]. Genomics,2009,93(2):146-151. |
| APA | Wang, Zhen,Ding, Guohui,Yu, Zhonghao,Liu, Lei,&Li, Yixue.(2009).Modeling the age distribution of gene duplications in vertebrate genome using mixture density.Genomics,93(2),146-151. |
| MLA | Wang, Zhen,et al."Modeling the age distribution of gene duplications in vertebrate genome using mixture density".Genomics 93.2(2009):146-151. |
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来源：中国科学院大学
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