Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia
文献类型：期刊论文
| 作者 | Li, Zhigang1; Zhang, Wei2,3; Wu, Minyuan1; Zhu, Shanshan2,3; Gao, Chao1; Sun, Lin1; Zhang, Ruidong1; Qiao, Nan2,3; Xue, Huiling2; Hu, Yamei1 |
| 刊名 | Blood
 |
| 出版日期 | 2009-11-12 |
| 卷号 | 114期号:20页码:4486-4493 |
| ISSN号 | 0006-4971 |
| DOI | 10.1182/blood-2009-04-218123 |
| 通讯作者 | Han, jing-dong j.(jdhan@genetics.ac.cn) |
| 英文摘要 | Pediatric acute lymphoblastic leukemia (all) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. subtype classification can be also achieved through gene expression profiling. however, how to apply such classifiers to a single patient and correctly diagnose the disease subtype in an independent patient group has not been addressed. furthermore, the underlying regulatory mechanisms responsible for the subtype-specific gene expression patterns are still largely unknown. here, by combining 3 published microarray datasets on 535 mostly white children's samples and generating a new dataset on 100 chinese children's all samples, we were able to (1) identify a 62-gene classifier with 97.6% accuracy from the white children's samples and validated it on the completely independent set of 100 chinese samples, and (2) uncover potential regulatory networks of all subtypes. the classifier we identified was, thus far, the only one that could be applied directly to a single sample and that sustained validation in a large independent patient group. our results also suggest that the etiology of all is largely the same among different ethnic groups, and that the transcription factor hubs in the predicted regulatory network might play important roles in regulating gene expression and development of all. (blood. 2009;114:4486-4493) |
| WOS关键词 | MICROARRAY DATA ; BIOCONDUCTOR ; SELECTION ; PROFILES ; CHILDREN ; DATABASE ; BIOLOGY ; TOOL |
| WOS研究方向 | Hematology |
| WOS类目 | Hematology |
| 语种 | 英语 |
| WOS记录号 | WOS:000271727500021 |
| 出版者 | AMER SOC HEMATOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394829 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Han, Jing-Dong J. |
| 作者单位 | 1.Capital Med Univ, Beijing Childrens Hosp, Beijing, Peoples R China 2.Chinese Acad Sci, Key Lab Mol & Dev Biol, Ctr Mol Syst Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Mol Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhigang,Zhang, Wei,Wu, Minyuan,et al. Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia[J]. Blood,2009,114(20):4486-4493. |
| APA | Li, Zhigang.,Zhang, Wei.,Wu, Minyuan.,Zhu, Shanshan.,Gao, Chao.,...&Han, Jing-Dong J..(2009).Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia.Blood,114(20),4486-4493. |
| MLA | Li, Zhigang,et al."Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia".Blood 114.20(2009):4486-4493. |
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来源：中国科学院大学
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