Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in caenorhabditis elegans
文献类型：期刊论文
| 作者 | Xiao, Hui1,2; Chen, Didi1,2; Fang, Zhou1,2; Xu, Jing1,2; Sun, Xiaojuan1,2; Song, Song1,2; Liu, Jiajia1; Yang, Chonglin1 |
| 刊名 | Molecular biology of the cell
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:1页码:21-32 |
| ISSN号 | 1059-1524 |
| DOI | 10.1091/mbc.e08-04-0441 |
| 通讯作者 | Yang, chonglin(clyang@genetics.ac.cn) |
| 英文摘要 | Appropriate clearance of apoptotic cells (cell corpses) is an important step of programmed cell death. although genetic and biochemical studies have identified several genes that regulate the engulfment of cell corpses, how these are degraded after being internalized in engulfing cell remains elusive. here, we show that vps-18, the caenorhabditis elegans homologue of yeast vps18p, is critical to cell corpse degradation. vps-18 is expressed and functions in engulfing cells. deletion of vps-18 leads to significant accumulation of cell corpses that are not degraded properly. furthermore, vps-18 mutation causes strong defects in the biogenesis of endosomes and lysosomes, thus affecting endosomal/lysosomal protein degradation. importantly, we demonstrate that phagosomes containing internalized cell corpses are unable to fuse with lysosomes in vps-18 mutants. our findings thus provide direct evidence for the important role of endosomal/lysosomal degradation in proper clearance of apoptotic cells during programmed cell death. |
| WOS关键词 | C-ELEGANS ; CORPSE ENGULFMENT ; DOMAIN PROTEIN ; DEEP-ORANGE ; ENDOCYTOSIS ; COMPLEX ; RECEPTOR ; FUSION ; DROSOPHILA ; GENETICS |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000262134800003 |
| 出版者 | AMER SOC CELL BIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2395196 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Chonglin |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Hui,Chen, Didi,Fang, Zhou,et al. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in caenorhabditis elegans[J]. Molecular biology of the cell,2009,20(1):21-32. |
| APA | Xiao, Hui.,Chen, Didi.,Fang, Zhou.,Xu, Jing.,Sun, Xiaojuan.,...&Yang, Chonglin.(2009).Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in caenorhabditis elegans.Molecular biology of the cell,20(1),21-32. |
| MLA | Xiao, Hui,et al."Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in caenorhabditis elegans".Molecular biology of the cell 20.1(2009):21-32. |
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来源：中国科学院大学
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