The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers
文献类型：期刊论文
| 作者 | Mao, Jing1,2; Gan, Zhihua1 |
| 刊名 | Macromolecular bioscience
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 9期号:11页码:1080-1089 |
| 关键词 | Block copolymers Controlled polymerization Drug delivery Enzymatic degradation Micelles |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.200900104 |
| 通讯作者 | Gan, zhihua(zhgan@iccas.ac.cn) |
| 英文摘要 | An amphiphilic diblock copolymer pg-b-pcl with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. the micellization and drug release of pg-b-pcl copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. the biodegradation of pg-b-pcl copolymers was studied with microspheres as research samples. it has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic pg block in pg-b-pcl copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres. |
| WOS关键词 | RING-OPENING POLYMERIZATION ; ONE-POT SYNTHESIS ; HYPERBRANCHED POLYGLYCEROLS ; TRIBLOCK COPOLYMERS ; FUNCTIONAL-GROUPS ; BLOCK-COPOLYMER ; NANOPARTICLES ; POLYGLYCIDOL ; BIODEGRADATION ; RELEASE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000271990000004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2395291 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gan, Zhihua |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Jing,Gan, Zhihua. The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers[J]. Macromolecular bioscience,2009,9(11):1080-1089. |
| APA | Mao, Jing,&Gan, Zhihua.(2009).The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers.Macromolecular bioscience,9(11),1080-1089. |
| MLA | Mao, Jing,et al."The influence of pendant hydroxyl groups on enzymatic degradation and drug delivery of amphiphilic poly[glycidol-block-(epsilon-caprolactone)] copolymers".Macromolecular bioscience 9.11(2009):1080-1089. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。