Human parthenogenetic embryonic stem cells: one potential resource for cell therapy
文献类型：期刊论文
| 作者 | Hao Jie1,2; Zhu WanWan1; Sheng Chao1; Yu Yang1; Zhou Qi1 |
| 刊名 | Science in china series c-life sciences
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 52期号:7页码:599-602 |
| 关键词 | Human parthenogenetic embryonic stem cell Therapeutic cloning Induced differentiation Imprinting Heterozygosis Cell therapy |
| ISSN号 | 1006-9305 |
| DOI | 10.1007/s11427-009-0096-2 |
| 通讯作者 | Zhou qi(qzhou@ioz.ac.cn) |
| 英文摘要 | Pluripotent stem cells derived from somatic cells through such processes as nuclear transfer or induced pluripotent stem (ips) cells present an important model for biomedical research and provide potential resources for cell replacement therapies. however, the overall efficiency of the conversional nuclear transfer is very low and the safety issue remains a major concern for ips cells. embryonic stem cells (escs) generated from parthenogenetic embryos are one attractive alternative as a source of histocompatible cells and tissues for cell therapy. recent studies on human parthenogenetic embryonic stem cells (hpg escs) have revealed that these escs are very similar to the hescs derived from ivf or in vivo produced blastocysts in gene expression and other characteristics, but full differentiation and development potential of these hpg escs have to be further investigated before clinical research and therapeutic interventions. to generate various pluripotent stem cells, diverse reprogramming techniques and approaches will be developed and integrated. this may help elucidate the fundamental mechanisms underlying reprogramming and stem cell biology, and ultimately benefit cell therapy and regenerative medicine. |
| WOS关键词 | NUCLEAR TRANSFER EMBRYOS ; JAN 20 2006 ; RETRACTED SEE ; PG 335 ; LINES ; BLASTOCYSTS ; MOUSE ; INSTABILITY ; STANDARDS ; ARTICLE |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000268514900002 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2395693 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou Qi |
| 作者单位 | 1.Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao Jie,Zhu WanWan,Sheng Chao,et al. Human parthenogenetic embryonic stem cells: one potential resource for cell therapy[J]. Science in china series c-life sciences,2009,52(7):599-602. |
| APA | Hao Jie,Zhu WanWan,Sheng Chao,Yu Yang,&Zhou Qi.(2009).Human parthenogenetic embryonic stem cells: one potential resource for cell therapy.Science in china series c-life sciences,52(7),599-602. |
| MLA | Hao Jie,et al."Human parthenogenetic embryonic stem cells: one potential resource for cell therapy".Science in china series c-life sciences 52.7(2009):599-602. |
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来源：中国科学院大学
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