Multiple-modulation effects of oridonin on the production of proinflammatory cytokines and neurotrophic factors in lps-activated microglia
文献类型：期刊论文
| 作者 | Xu, Yan1,3; Xue, Yang2; Wang, Ying2; Feng, Dechun1,3; Lin, Shuting2; Xu, Lingyun1,2 |
| 刊名 | International immunopharmacology
 |
| 出版日期 | 2009-03-01 |
| 卷号 | 9期号:3页码:360-365 |
| 关键词 | Oridonin Lipopolysaccharide Nf-kappa b Ngf |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2009.01.002 |
| 通讯作者 | Xu, lingyun(lyxu@sibs.ac.cn) |
| 英文摘要 | Microglial activation has been implicated in many neurological disorders for its inflammatory and/or neurotrophic effects. in this study, we investigated the effects upon activated microglia of oridonin (ori), an effective component isolated from rabdosia rubescens. we pretreated rat primary microglia with or without ori, then stimulated with lipopolysaccharide (lps). we found that ori pretreatment inhibited the release of proinflammatory mediators including nitric oxide (no). tumor necrosis factor-alpha (tnf-alpha), interleukin-1 beta (il-1 beta) and interleukin-6 (il-6). such suppressive effects were accompanied by inhibition of dna binding activity of the critical transcription factor nuclear factor-kappa b (nf-kappa b). in addition, on upregulated the production of the neurotrophic factor, nerve growth factor (ngf). our findings suggest that ori may have anti-inflammatory and neuroregulatory effects through modulation of multiple functions of microglia. (c) 2009 elsevier b.v. all rights reserved |
| WOS关键词 | NF-KAPPA-B ; NITRIC-OXIDE SYNTHASE ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; TUMOR-NECROSIS-FACTOR ; PARKINSONS-DISEASE ; TRANSGENIC MICE ; GROWTH-FACTOR ; CELLS ; BRAIN |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| WOS类目 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000264507100015 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2396411 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Lingyun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Univ, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yan,Xue, Yang,Wang, Ying,et al. Multiple-modulation effects of oridonin on the production of proinflammatory cytokines and neurotrophic factors in lps-activated microglia[J]. International immunopharmacology,2009,9(3):360-365. |
| APA | Xu, Yan,Xue, Yang,Wang, Ying,Feng, Dechun,Lin, Shuting,&Xu, Lingyun.(2009).Multiple-modulation effects of oridonin on the production of proinflammatory cytokines and neurotrophic factors in lps-activated microglia.International immunopharmacology,9(3),360-365. |
| MLA | Xu, Yan,et al."Multiple-modulation effects of oridonin on the production of proinflammatory cytokines and neurotrophic factors in lps-activated microglia".International immunopharmacology 9.3(2009):360-365. |
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来源：中国科学院大学
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