Effect of different regions of nogo-a on the differentiation of neural progenitors
文献类型：期刊论文
| 作者 | Gao, Yuan1,2; Xiao, Zhifeng1; Chen, Bing1; Wang, Bin1; Han, Jin1; Zhao, Yannan1; Zhang, Jing1; Dai, Jianwu1 |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2009-07-24 |
| 卷号 | 458期号:3页码:132-135 |
| 关键词 | Nogo-a Functional region Neural progenitors Differentiation |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2009.04.034 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Nogo-a is an inhibitor of neurite outgrowth and axonal regeneration after cns injury. several functional regions including nogo-66 were identified to mediate the inhibitory effect of nogo-a. we have reported that nogo-66 could promote neural progenitors to differentiate into glial cells. here we exam three other regions of nogo-a and show two of them also mediate the differentiation of neural progenitors. a 172-residues n-terminal region and a 37-residues c-terminal region of nogo-a both could inhibit neuronal differentiation and promoted glial cell formation. this study illustrated that nogo-a had multiple functional domains on the behavior of neuronal cells. the inhibitory effect of neural differentiation of nogo-a may also contribute to its restraint of cns repair. (c) 2009 published by elsevier ireland ltd. |
| WOS关键词 | NEURITE OUTGROWTH ; AXONAL REGENERATION ; NERVOUS-SYSTEM ; STEM-CELLS ; ADULT-RAT ; INHIBITOR ; EXPRESSION ; PATHWAY ; PROTEIN ; APOPTOSIS |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000266761200008 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2396639 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Xiao, Zhifeng,Chen, Bing,et al. Effect of different regions of nogo-a on the differentiation of neural progenitors[J]. Neuroscience letters,2009,458(3):132-135. |
| APA | Gao, Yuan.,Xiao, Zhifeng.,Chen, Bing.,Wang, Bin.,Han, Jin.,...&Dai, Jianwu.(2009).Effect of different regions of nogo-a on the differentiation of neural progenitors.Neuroscience letters,458(3),132-135. |
| MLA | Gao, Yuan,et al."Effect of different regions of nogo-a on the differentiation of neural progenitors".Neuroscience letters 458.3(2009):132-135. |
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来源：中国科学院大学
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