Stat3 mediates protection from liver inflammation after partial hepatectomy
文献类型：期刊论文
| 作者 | Xu, Yan1,3; Feng, Dechun1,3; Wang, Ying2; Luo, Qingqiong2; Xu, Lingyun1,2 |
| 刊名 | Cellular physiology and biochemistry
 |
| 出版日期 | 2009 |
| 卷号 | 23期号:4-6页码:379-386 |
| 关键词 | Cona Hepatoprotection Immune challenge Liver regeneration Stat3 |
| ISSN号 | 1015-8987 |
| DOI | 10.1159/000218184 |
| 通讯作者 | Xu, lingyun(lyxu@sibs.ac.cn) |
| 英文摘要 | Background/aims: the liver has the unique capacity to restore its mass by hepatocyte proliferation after injury or transplantation. the present study investigated whether the regenerating liver responds to immune stimuli in the same way as the quiescent one. methods: we performed partial hepatectomy (phx) in mice, then stimulated the mice with concanavalin a (cona) to study their immune responses. plasma alanine aminotransferase (alt) and cytokine levels as well as liver inflammatory infiltration were measured to evaluate liver damage. transcriptional factors were further detected to study the underlining mechanisms. results: our results showed that phx mice were resistant to cona-induced liver inflammation and injury, as evidenced by both morphological and biochemical observations. then we went further to study the mechanisms. we found marked signal transducer and activator of transcription 3 (stat3) activation 48 hours after phx. when stat3 activation was blocked with its inhibitor jsi-124, phx mice also developed severe liver inflammation after cona stimulation. conclusion: the regenerating liver is resistant to cona induced immune assaulting, and stat3 is the major player in the protection process. copyright (c) 2009 s. karger ag, basel |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; GROWTH-FACTOR ; IMMUNE-RESPONSE ; CONCANAVALIN-A ; REGENERATION ; MICE ; HEPATITIS ; INJURY ; HEPATOCYTES ; PATHWAY |
| WOS研究方向 | Cell Biology ; Physiology |
| WOS类目 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000265864700016 |
| 出版者 | KARGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2396736 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Lingyun |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Med, Shanghai 200030, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200030, Peoples R China 3.Chinese Acad Sci, Grad Univ, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yan,Feng, Dechun,Wang, Ying,et al. Stat3 mediates protection from liver inflammation after partial hepatectomy[J]. Cellular physiology and biochemistry,2009,23(4-6):379-386. |
| APA | Xu, Yan,Feng, Dechun,Wang, Ying,Luo, Qingqiong,&Xu, Lingyun.(2009).Stat3 mediates protection from liver inflammation after partial hepatectomy.Cellular physiology and biochemistry,23(4-6),379-386. |
| MLA | Xu, Yan,et al."Stat3 mediates protection from liver inflammation after partial hepatectomy".Cellular physiology and biochemistry 23.4-6(2009):379-386. |
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来源：中国科学院大学
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