Metabonomic studies on intact livers and liver extracts from rats treated with neodymium nitrate
文献类型：期刊论文
| 作者 | Liao Pei-Qiu1,2; Wei Lai1,2; Liu Wei3; Wu Yi-Jie1; Li Xiao-Jing1; Ni Jia-Zuan1; Pei Feng-Kui1 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2009-06-10 |
| 卷号 | 30期号:6页码:1116-1120 |
| 关键词 | Nuclear magnetic resonance Metabonomics Pattern recognition Liver Neodymium nitrate Biochemical effect |
| ISSN号 | 0251-0790 |
| 通讯作者 | Li xiao-jing(xjli@ciac.jl.cn) |
| 英文摘要 | The biochemical effects of neodymium nitrate were studied by nmr spectroscopic-based metabonomic approach. male wistar rats were treated intraperitoneally with different doses(2, 10 and 50 mg/kg body weight) of nd(no(3))(3). liver samples from nd(3+)-treated rats were analyzed either by 600 mhz (1)h mas nmr techniques for intact liver or using high resolution( liquid state) (1)h nmr for liver chloroform/water/methanol extracts. all nmr spectra data were analyzed by pattern recognition using principal components analysis. liver lesions induced by nd(no(3))(3) were represented by increased triglyceride, leucine (isoleucine), lactate, alanine, pyruvate, phosphocholine and glucose concentration, and reduced trimethylamine n-oxide(tmao) concentration in liver. histopathology examination showed cell necrosis and inflammation in the liver of 50 mg/kg body weight dosed rats. it was demonstrated that neodymium nitrate could cause damages to rats liver by disturbing the energy metabolism (glucose and lipid metabolism) and amino acid metabolism in the liver. |
| WOS关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY ; PATTERN-RECOGNITION ; ALPHA-NAPHTHYLISOTHIOCYANATE ; NMR-SPECTROSCOPY ; H-1-NMR ; LANTHANUM ; TOXICITY ; TISSUES ; CERIUM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000267873700012 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2397245 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li Xiao-Jing |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Jilin Prov Acad Tradit Chinese Med, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao Pei-Qiu,Wei Lai,Liu Wei,et al. Metabonomic studies on intact livers and liver extracts from rats treated with neodymium nitrate[J]. Chemical journal of chinese universities-chinese,2009,30(6):1116-1120. |
| APA | Liao Pei-Qiu.,Wei Lai.,Liu Wei.,Wu Yi-Jie.,Li Xiao-Jing.,...&Pei Feng-Kui.(2009).Metabonomic studies on intact livers and liver extracts from rats treated with neodymium nitrate.Chemical journal of chinese universities-chinese,30(6),1116-1120. |
| MLA | Liao Pei-Qiu,et al."Metabonomic studies on intact livers and liver extracts from rats treated with neodymium nitrate".Chemical journal of chinese universities-chinese 30.6(2009):1116-1120. |
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来源：中国科学院大学
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