Direct experimental evidence of ternary diastereomeric complexes in chiral separations of phenylglycine enatiomers with chiral mobile phase by rp-hplc
文献类型：期刊论文
| 作者 | Yu Qing; Cao Jie; Zhang Cheng-Gen |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2009-05-10 |
| 卷号 | 30期号:5页码:988-991 |
| 关键词 | Chiral mobile phase Rp-hplc Phenylglycin Mass spectrometry Theoretical calculation |
| ISSN号 | 0251-0790 |
| 通讯作者 | Cao jie() |
| 英文摘要 | Chiral separation of d-, l-phenylglycine by rp-hplc was accomplished by adding a complex of optically active l-phe-cu(2+), to the mobile phase. chiral separation mechanism was further elucidated in light of unambiguously assigning the structure of the elutents from rp-hplc by taking advantage of tandem mass spectrometry due to its unique capability of structural identification of the unknows. mass spectrometry results revealed that the pair of eluents respresented a pair of ternary copper complexes with mixed ligands, providing the first experimental evidence. these complexes are diastereoisomer in nature. the optimized configuration of the diastereoisomer was predicted by theoretical calculation. in addition, the effects of the ratio of cu(2+), to l-phe, ph of chiral mobile phase as well as the concentrations of methanol were investigated. |
| WOS关键词 | AMINO-ACIDS ; ENANTIOMERS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000266417200029 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2397263 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cao Jie |
| 作者单位 | Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu Qing,Cao Jie,Zhang Cheng-Gen. Direct experimental evidence of ternary diastereomeric complexes in chiral separations of phenylglycine enatiomers with chiral mobile phase by rp-hplc[J]. Chemical journal of chinese universities-chinese,2009,30(5):988-991. |
| APA | Yu Qing,Cao Jie,&Zhang Cheng-Gen.(2009).Direct experimental evidence of ternary diastereomeric complexes in chiral separations of phenylglycine enatiomers with chiral mobile phase by rp-hplc.Chemical journal of chinese universities-chinese,30(5),988-991. |
| MLA | Yu Qing,et al."Direct experimental evidence of ternary diastereomeric complexes in chiral separations of phenylglycine enatiomers with chiral mobile phase by rp-hplc".Chemical journal of chinese universities-chinese 30.5(2009):988-991. |
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来源：中国科学院大学
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