The urea-dipeptides show stronger h-bonding propensity to nucleate beta-sheetlike assembly than natural sequence
文献类型：期刊论文
| 作者 | Ke, Damei1,2; Zhan, Chuanlang1; Li, Xiao1,2; Li, Alexander. D. Q.3; Yao, Jiannian1 |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2009-09-26 |
| 卷号 | 65期号:39页码:8269-8276 |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2009.07.048 |
| 通讯作者 | Zhan, chuanlang(clzhan@iccas.ac.cn) |
| 英文摘要 | In this article, we report the distinct solution behavior of a set of urea-dipeptides to that of natural sequence. the urea-dipeptides adopt beta-folding conformations and form into beta-sheetlike assembly in chloroform. most surprisedly, the urea-dipeptides tend to form interpeptide h-bonding interactions even at a concentration of as low as 0 1 mm, while the natural sequence shows h-bonding propensity at a concentration of about 7 mm, indicating that the urea-dipeptides show much stronger h-bonding propensity to nucleate formation of beta-sheetlike assembly than the natural sequence cd spectra reveal that the investigated urea-dipeptides have two negative cd bands, respectively, around 217 nm and 224 nm, supporting the beta-folding conformations and in turn formation of beta-sheetlike assembly. the beta-sheetlike assembly is also confirmed by the xrd reflections, which give two typical d-spacings of 12 7 and 4 8 angstrom, respectively, corresponding to stacking periodicity of the beta-sheets and the spacing between peptide backbones running orthogonal to the beta-sheet axis. (c) 2009 elsevier ltd all rights reserved |
| WOS关键词 | SOLUBLE EPOXIDE HYDROLASES ; SOLID-PHASE SYNTHESIS ; MOLECULAR-SOLIDS ; CIRCULAR-DICHROISM ; INHIBITORS ; DESIGN ; PEPTIDE ; PROTEINASE ; OLIGOUREAS ; SCAFFOLDS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000270121400027 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2397827 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhan, Chuanlang |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Lab Photochem, Inst Chem, PR-100190 Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, PR-100039 Beijing, Peoples R China 3.Washington State Univ, Dept Chem, Pullman, WA 99164 USA |
| 推荐引用方式 GB/T 7714 | Ke, Damei,Zhan, Chuanlang,Li, Xiao,et al. The urea-dipeptides show stronger h-bonding propensity to nucleate beta-sheetlike assembly than natural sequence[J]. Tetrahedron,2009,65(39):8269-8276. |
| APA | Ke, Damei,Zhan, Chuanlang,Li, Xiao,Li, Alexander. D. Q.,&Yao, Jiannian.(2009).The urea-dipeptides show stronger h-bonding propensity to nucleate beta-sheetlike assembly than natural sequence.Tetrahedron,65(39),8269-8276. |
| MLA | Ke, Damei,et al."The urea-dipeptides show stronger h-bonding propensity to nucleate beta-sheetlike assembly than natural sequence".Tetrahedron 65.39(2009):8269-8276. |
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来源：中国科学院大学
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