Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats
文献类型：期刊论文
| 作者 | Han, Yi1,2,3; Yu, Long-Chuan1,2 |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2009-04-17 |
| 卷号 | 454期号:1页码:101-104 |
| 关键词 | Anti-nociception Oxytocin Central nucleus of amygdala Hindpaw withdrawal latency |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2009.02.062 |
| 通讯作者 | Yu, long-chuan(yulc@pku.edu.cn) |
| 英文摘要 | Studies have demonstrated that oxytocin plays important roles in pain modulation in the central nervous system. oxytocin-ergic neurons are found in paraventricular nucleus and supraoptic nucleus of the hypothalamus. the oxytocin-ergic neurons send fibers from hypothalamus to amygdala and high density of oxytocin receptors are found in the central nucleus of amygdala (cea). the present study was performed to investigate the influences of oxytocin and its receptors on nociceptive responses in the cea of rats. intra-cea injection of 0.1, 0.5 or 1 nmol of oxytocin induced dose-dependent increases in the handpaw withdrawal latency induced by noxious thermal and mechanical stimulation in rats. the oxytocin-induced anti-nociception could be blocked by the selective oxytocin antagonist 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin. the present study demonstrated that oxytocin and its receptors are involved in nociceptive modulation in the cea of rats. (c) 2009 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | OPIOID RECEPTORS ; NEUROPATHIC PAIN ; SPINAL-CORD ; ANTINOCICEPTION ; INFLAMMATION ; ACCUMBENS ; INTACT ; MODEL |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000265275300021 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398410 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Long-Chuan |
| 作者单位 | 1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 3.Kunming Med Coll, Fac Basic Med Sci, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Yi,Yu, Long-Chuan. Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats[J]. Neuroscience letters,2009,454(1):101-104. |
| APA | Han, Yi,&Yu, Long-Chuan.(2009).Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats.Neuroscience letters,454(1),101-104. |
| MLA | Han, Yi,et al."Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats".Neuroscience letters 454.1(2009):101-104. |
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来源：中国科学院大学
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