Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in caenorhabditis elegans
文献类型：期刊论文
| 作者 | Shen, Qinfang1,2; Qin, Fengsong1,2; Gao, Zhiyang1; Cui, Jie1,2; Xiao, Hui1,2; Xu, Zhiheng1; Yang, Chonglin1 |
| 刊名 | Molecular and cellular biology
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 29期号:14页码:3881-3893 |
| ISSN号 | 0270-7306 |
| DOI | 10.1128/mcb.01509-08 |
| 通讯作者 | Yang, chonglin(clyang@genetics.ac.cn) |
| 英文摘要 | In caenorhabditis elegans, the central cell-killing process is essentially controlled by the interplay of four apoptotic factors: egl-1/bh3-only protein, ced-9/bcl2, ced-4/apaf1, and ced-3/caspase. in cells destined to die, egl-1 binds to ced-9 and results in the release of ced-4 from the mitochondrion-tethered ced-9 ced-4 complex to the perinucleus, which facilitates processing of the ced-3 caspase to cause apoptosis. however, whether additional factors exist to regulate the cell-killing process remains largely unknown. we have identified here wan-1, the c. elegans ortholog of mammalian adenine nucleotide translocator, as an important cell death regulator. genetic inactivation of wan-1 significantly suppressed both somatic and germ line cell deaths in c. elegans. consistently, chemical inhibition of wan-1 activity also caused strong reduction of germ line apoptosis. wan-1 localizes to mitochondria and can form complex with both ced-4 and ced-9. importantly, the cell death initiator egl-1 can disrupt the interaction between ced-9 and wan-1. in addition, overexpression of wan-1 induced ectopic cell killing dependently on the core cell death pathway. these findings suggest that wan-1 is involved in the central cell-killing process and cooperates with the core cell death machinery to promote programmed cell death in c. elegans. |
| WOS关键词 | PERMEABILITY TRANSITION PORE ; C-ELEGANS ; MITOCHONDRIAL CONTROL ; CED-3 ACTIVATION ; ADP/ATP CARRIER ; EGL-1 ; REGULATORS ; COMPLEX ; DEGRADATION ; ENGULFMENT |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267939300006 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398420 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Chonglin |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Qinfang,Qin, Fengsong,Gao, Zhiyang,et al. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in caenorhabditis elegans[J]. Molecular and cellular biology,2009,29(14):3881-3893. |
| APA | Shen, Qinfang.,Qin, Fengsong.,Gao, Zhiyang.,Cui, Jie.,Xiao, Hui.,...&Yang, Chonglin.(2009).Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in caenorhabditis elegans.Molecular and cellular biology,29(14),3881-3893. |
| MLA | Shen, Qinfang,et al."Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in caenorhabditis elegans".Molecular and cellular biology 29.14(2009):3881-3893. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。