Gene expression profiling during early response to injury and microbial challenges in the silkworm, bombyx mori
文献类型：期刊论文
| 作者 | Liu, Fei; Ling, Erjun; Wu, Shan |
| 刊名 | Archives of insect biochemistry and physiology
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 72期号:1页码:16-33 |
| 关键词 | Insect immunity Serratia marcescens Staphylococcus aureus Beauveria bassiana Bombyx mori Gene expression Real-time pcr |
| ISSN号 | 0739-4462 |
| DOI | 10.1002/arch.20320 |
| 通讯作者 | Wu, shan(wss_tea@hotmail.com) |
| 英文摘要 | The identify, bombyx mori genes involved in the early response to injury and microbial challenge, we performed genome-wide gene expression-profiling experiments using oligonucleolide data microarrays. of approximately 23, 000 genes examined, 465 displayed changes in mrna expression levels. 0 these, 306 were induced and 159 were repressed in response to injury (injection with phosphate buffer saline) or challenges by gram-negative (serratia marcescens), gram-positive bacteria (staphylococcus aureus), or fungus (beauveria bassiana). many of these differentially expressed genes can be assigned to specific functional groups of the innate immune response, including recognition, signaling, melanization and coagulation, and antimicrobial peptides. seventeen percent of differentially expressed genes encode proteins with no obvious similarity to known functional domains. of particular interest is a member of the juvenile hormone-binding protein family, which was highly induced by both injury and microbial challenges. the possible role of juvenile hormone in innate immunity is discussed. (c) 2009 wiley periodicals, inc. |
| WOS关键词 | ANTIMICROBIAL PEPTIDE GENES ; BETA-1,3-GLUCAN RECOGNITION PROTEIN ; PROPHENOLOXIDASE ACTIVATING SYSTEM ; DROSOPHILA IMMUNE-RESPONSE ; HORMONE BINDING-PROTEIN ; MOSQUITO AEDES-AEGYPTI ; GENOME-WIDE ANALYSIS ; MANDUCA-SEXTA ; DOMESTICATED SILKWORM ; JUVENILE-HORMONE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Entomology ; Physiology |
| WOS类目 | Biochemistry & Molecular Biology ; Entomology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269362200002 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398594 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wu, Shan |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol,Res Ctr Insect Sci, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fei,Ling, Erjun,Wu, Shan. Gene expression profiling during early response to injury and microbial challenges in the silkworm, bombyx mori[J]. Archives of insect biochemistry and physiology,2009,72(1):16-33. |
| APA | Liu, Fei,Ling, Erjun,&Wu, Shan.(2009).Gene expression profiling during early response to injury and microbial challenges in the silkworm, bombyx mori.Archives of insect biochemistry and physiology,72(1),16-33. |
| MLA | Liu, Fei,et al."Gene expression profiling during early response to injury and microbial challenges in the silkworm, bombyx mori".Archives of insect biochemistry and physiology 72.1(2009):16-33. |
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来源：中国科学院大学
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