Induction of cd4+cd25+foxp3+regulatory t cell response by glatiramer acetate in type 1 diabetes
文献类型：期刊论文
| 作者 | Cui, Guoliang1; Zhang, Yuebo1; Gong, Zhenwei1; Zhang, Jingwu Z.2; Zang, Ying Qin1 |
| 刊名 | Cell research
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 19期号:5页码:574-583 |
| 关键词 | Glatiramer acetate Regulatory t cell Foxp3 Type 1 diabetes |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2009.12 |
| 通讯作者 | Zang, ying qin(yqin@sibs.ac.cn) |
| 英文摘要 | Glatiramer acetate (ga) is an immunomodulatory peptide drug used to treat multiple sclerosis. its treatment effect has been expanded to other autoimmune conditions such as uveoretinitis, inflammatory bowel disease, graft rejection and hepatic fibrosis. here, we report that ga was effective in altering the clinical course of diabetes in cyclophosphamide (cy)-potentiated non-obese diabetic (cy-nod) mice. treatment with ga significantly reduced the diabetic rate in the mice and ameliorated insulitis, which coincided with increased cd4+cd25+foxp3+ t cell response in treated mice. ga treatment led to increased expression of transcription factor foxp3 and elevated production of interleukin-4 (il-4) both in vivo and in vitro. it was evident that the effect of ga on up-regulation of foxp3 was mediated partially through il-4. il-4 was found to maintain foxp3 expression and regulatory function of cd4+cd25+ regulatory t cells (tregs). this study provides new evidence that ga has treatment potential for type 1 diabetes through the induction of tregs and that increased il-4 production is partially responsible for the enhanced treg's function in ga treatment. |
| WOS关键词 | TRANSCRIPTION FACTOR FOXP3 ; MYELIN BASIC-PROTEIN ; SUPPRESSOR FUNCTION ; MULTIPLE-SCLEROSIS ; SYNTHETIC COPOLYMER-1 ; CUTTING EDGE ; ACTIVATION ; MODULATION ; CONVERSION ; COPAXONE |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000266527600007 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398638 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zang, Ying Qin |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Key Lab Nutr & Metab, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Guoliang,Zhang, Yuebo,Gong, Zhenwei,et al. Induction of cd4+cd25+foxp3+regulatory t cell response by glatiramer acetate in type 1 diabetes[J]. Cell research,2009,19(5):574-583. |
| APA | Cui, Guoliang,Zhang, Yuebo,Gong, Zhenwei,Zhang, Jingwu Z.,&Zang, Ying Qin.(2009).Induction of cd4+cd25+foxp3+regulatory t cell response by glatiramer acetate in type 1 diabetes.Cell research,19(5),574-583. |
| MLA | Cui, Guoliang,et al."Induction of cd4+cd25+foxp3+regulatory t cell response by glatiramer acetate in type 1 diabetes".Cell research 19.5(2009):574-583. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。