The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence
文献类型：期刊论文
| 作者 | Ke, Damei1,2; Zhan, Chuanlang1; Li, Xiao1,2; Wang, Yaobing1,2; Li, Alexander D. Q.3; Yao, Jiannian1 |
| 刊名 | Tetrahedron letters
 |
| 出版日期 | 2009-07-08 |
| 卷号 | 50期号:27页码:3926-3928 |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2009.04.067 |
| 通讯作者 | Zhan, chuanlang(clzhan@iccas.ac.cn) |
| 英文摘要 | In this letter, we report solution behavior of two imide-dipeptides containing l-alanine and l-leucine residues. in contrast to natural sequence, the imide-dipeptidyl backbone contains distinct features: self-pairing h-bonds, topochemical symmetry, a peptide polindron sequence, and different orientations of side chains. the solution behavior in chloroform reveals that both the imide-dipeptides adopt beta-folding conformations and form beta-sheet-like assembly. most surprisingly, they form more stable and stronger h-bonds than the natural counterpart, and thus show different h-bonding patterns from the natural sequence. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | N,N'-LINKED OLIGOUREAS ; STRAND PEPTIDOMIMETICS ; PROTEASE INHIBITORS ; SECONDARY STRUCTURE ; NMR-SPECTROSCOPY ; AMINO-ACID ; AT-TIDES ; DESIGN ; FOLDAMERS ; PEPTIDES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000266890000050 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398644 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhan, Chuanlang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Lab Photochem, BNLMS, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Washington State Univ, Dept Chem, Pullman, WA 99164 USA |
| 推荐引用方式 GB/T 7714 | Ke, Damei,Zhan, Chuanlang,Li, Xiao,et al. The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence[J]. Tetrahedron letters,2009,50(27):3926-3928. |
| APA | Ke, Damei,Zhan, Chuanlang,Li, Xiao,Wang, Yaobing,Li, Alexander D. Q.,&Yao, Jiannian.(2009).The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence.Tetrahedron letters,50(27),3926-3928. |
| MLA | Ke, Damei,et al."The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence".Tetrahedron letters 50.27(2009):3926-3928. |
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来源：中国科学院大学
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