An essential role for rig-i in toll-like receptor-stimulated phagocytosis
文献类型：期刊论文
| 作者 | Kong, Ling2,5; Sun, Lei2,5; Zhang, Hongxin1; Liu, Qin2; Liu, Ye2; Qin, Linhua2; Shi, Guojun2,5; Hu, Jun-Hao2,5; Xu, Ajing2; Sun, Yue-Ping1 |
| 刊名 | Cell host & microbe
 |
| 出版日期 | 2009-08-20 |
| 卷号 | 6期号:2页码:150-161 |
| ISSN号 | 1931-3128 |
| DOI | 10.1016/j.chom.2009.06.008 |
| 通讯作者 | Wang, zhu-gang(zhugangw@shsmu.edu.cn) |
| 英文摘要 | Retinoic acid-inducible gene-i (rig-i) plays an important role in antiviral response by recognizing double-stranded rna. here we demonstrate an unanticipated role of rig-i in toll-like receptor (tlr)-stimulated phagocytosis. stimulation with lipopolysaccharide, (lps), a ligand of tlr4, induced the expression of rig-i in macrophages. depletion of rig-i by rnai or gene targeting inhibited the lps-induced phagocytosis of bacteria. cellular processes involved in phagocytosis, such as small gtpase cdc42/rac1 activation, actin polymerization, and actin-regulator arp2/3 recruitment, were also impaired in rig-i-deficient macrophages activated by lps. moreover, rig-i(-/-) mice were found to be more susceptible to infection with escherichia coli as compared to wild-type mice. thus, the regulatory functions of rig-i are strikingly broad, including a role not only in antiviral responses but in antibacterial responses as well. |
| WOS关键词 | INDUCIBLE GENE-I ; PHAGOSOME MATURATION ; SIGNAL-TRANSDUCTION ; ANTIVIRAL RESPONSE ; ENDOTHELIAL-CELLS ; ADAPTER PROTEIN ; INNATE IMMUNITY ; ACTIN DYNAMICS ; KAPPA-B ; PATHWAY |
| WOS研究方向 | Microbiology ; Parasitology ; Virology |
| WOS类目 | Microbiology ; Parasitology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269268900007 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398664 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhu-Gang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Dept Med Genet, Genet Engn Lab, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci,Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci, Shanghai 200025, Peoples R China 3.RuiJin Hosp, State Key Lab Med Genom, Shanghai 200025, Peoples R China 4.RuiJin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China 5.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Informat Ctr Life Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Ling,Sun, Lei,Zhang, Hongxin,et al. An essential role for rig-i in toll-like receptor-stimulated phagocytosis[J]. Cell host & microbe,2009,6(2):150-161. |
| APA | Kong, Ling.,Sun, Lei.,Zhang, Hongxin.,Liu, Qin.,Liu, Ye.,...&Ge, Bao-Xue.(2009).An essential role for rig-i in toll-like receptor-stimulated phagocytosis.Cell host & microbe,6(2),150-161. |
| MLA | Kong, Ling,et al."An essential role for rig-i in toll-like receptor-stimulated phagocytosis".Cell host & microbe 6.2(2009):150-161. |
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来源：中国科学院大学
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