Dickkopf-1 enhances migration of hek293 cell by beta-catenin/e-cadherin degradation
文献类型：期刊论文
| 作者 | Kuang, Hai-Bin1,2,3; Miao, Cheng-Lin1,2; Guo, Wei-Xiang1,2; Peng, Sha1,2; Cao, Yu-Jing1; Duan, En-Kui1 |
| 刊名 | Frontiers in bioscience
 |
| 出版日期 | 2009 |
| 卷号 | 14页码:2212-u3858 |
| 关键词 | Dkk-1 Migration Adhesion Beta-catenin E-cadherin |
| ISSN号 | 1093-9946 |
| DOI | 10.2741/3373 |
| 通讯作者 | Duan, en-kui(duane@ioz.ac.cn) |
| 英文摘要 | Migration is an important process during cellular activity and embryo development. we recently showed that dickkopf-1(dkk-1), an antagonist of wnt/ beta-catenin signaling pathway, could promote trophoblast cell invasion during murine placentation. however, mechanism of dkk-1 action on cell migration was not clear. the objective of this study was to further evaluate the effect of dkk-1 on cell migration and to identify the underlining mechanisms. functional assays with stable dkk-1 transfected hek293 cells revealed that dkk-1 expression increased cell migration by decreasing cell-cell adhesion, not cell-matrix adhesion. treatment with licl and genistein (widely used inhibitor of glycogen synthase kinase-3 and tyrosine protein kinase, respectively.) could inhibit the migration effect of dkk-1, and significantly increased the membrane localization of beta-catenin and e-cadherin in hek293 cells transfected with dkk-1. further data showed that hek293 cells transfected with dkk-1 have significantly decreased accumulation of both beta-catenin and e-cadherin at the cell membrane. together, our data suggest that dkk-1 stimulates the release of beta-catenin from cell membrane and facilitates cell migration which accompanies degradation of beta-catenin/e-cadherin. |
| WOS关键词 | TYROSINE PHOSPHORYLATION ; SIGNAL-TRANSDUCTION ; BONE METASTASES ; WNT ANTAGONIST ; HUMAN DKK-1 ; ADHESION ; CANCER ; PROTEINS ; OVEREXPRESSION ; ASSOCIATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000262352400146 |
| 出版者 | FRONTIERS IN BIOSCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398890 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Duan, En-Kui |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Nanchang Univ, Sch Med, Dept Physiol, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Hai-Bin,Miao, Cheng-Lin,Guo, Wei-Xiang,et al. Dickkopf-1 enhances migration of hek293 cell by beta-catenin/e-cadherin degradation[J]. Frontiers in bioscience,2009,14:2212-u3858. |
| APA | Kuang, Hai-Bin,Miao, Cheng-Lin,Guo, Wei-Xiang,Peng, Sha,Cao, Yu-Jing,&Duan, En-Kui.(2009).Dickkopf-1 enhances migration of hek293 cell by beta-catenin/e-cadherin degradation.Frontiers in bioscience,14,2212-u3858. |
| MLA | Kuang, Hai-Bin,et al."Dickkopf-1 enhances migration of hek293 cell by beta-catenin/e-cadherin degradation".Frontiers in bioscience 14(2009):2212-u3858. |
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来源：中国科学院大学
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