Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction
文献类型：期刊论文
| 作者 | Zhang, Jing1,2; Ding, Liang3; Zhao, Yannan1,2; Sun, Wenjie1; Chen, Bing1; Lin, Hang1; Wang, Xia1; Zhang, Lujie3; Xu, Biao3; Dai, Jianwu1 |
| 刊名 | Circulation
 |
| 出版日期 | 2009-04-07 |
| 卷号 | 119期号:13页码:1776-1784 |
| 关键词 | Vascular endothelial growth factors Collagen Angiogenesis Myocardial infarction |
| ISSN号 | 0009-7322 |
| DOI | 10.1161/circulationaha.108.800565 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Background-vascular endothelial growth factor (vegf) is an important active protein for the induction of angiogenesis and improvement in cardiac function after myocardial ischemia; however, the lack of a delivery system targeted to the injured myocardium reduces the local therapeutic efficacy of vegf and increases its possible adverse effects. methods and results-we produced a fusion protein (cbd-vegf) consisting of vegf and a collagen-binding domain (cbd). the fusion protein specifically bound to type i collagen in vitro. in addition, cbd-vegf promoted human umbilical vein endothelial cell proliferation after binding to collagen, which indicates that it retained both growth factor activity and collagen-binding ability. when implanted subcutaneously in rats, collagen membranes loaded with cbd-vegf were significantly vascularized. after it was injected into rats with acute myocardial infarction, cbd-vegf was largely retained in the cardiac extracellular matrix, in which collagen i was rich. four weeks after vegf or cbd-vegf was injected into the infarct border zone, cardiac function detected by echocardiography and hemodynamics was preserved in the cbd-vegf group. administration of cbd-vegf also induced reduction of scar size, whereas native vegf did not have these effects. in addition, a significant increase in the number of capillary vessels in infarcted hearts was found in the cbd-vegf group. conclusions-the injection of cbd-vegf improved cardiac function in rats with induced acute myocardial infarction. this could potentially provide a new treatment option for myocardial infarction. (circulation. 2009; 119: 1776-1784.) |
| WOS关键词 | PROGENITOR CELLS ; ISCHEMIC-MYOCARDIUM ; FACTOR DELIVERY ; GENE-THERAPY ; ANGIOGENESIS ; VEGF ; NEOVASCULARIZATION ; EXPRESSION ; HEART ; MOBILIZATION |
| WOS研究方向 | Cardiovascular System & Cardiology |
| WOS类目 | Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease |
| 语种 | 英语 |
| WOS记录号 | WOS:000264928800012 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2398965 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 3.Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Cardiol, Nanjing 210008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing,Ding, Liang,Zhao, Yannan,et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction[J]. Circulation,2009,119(13):1776-1784. |
| APA | Zhang, Jing.,Ding, Liang.,Zhao, Yannan.,Sun, Wenjie.,Chen, Bing.,...&Dai, Jianwu.(2009).Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction.Circulation,119(13),1776-1784. |
| MLA | Zhang, Jing,et al."Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction".Circulation 119.13(2009):1776-1784. |
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来源：中国科学院大学
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