Amphiphilic peg-co-pgl-g-pcl copolymer brushes: synthesis, micellization and controlled drug delivery
文献类型：期刊论文
| 作者 | Mao, Jing1,2; Gan, Zhihua1 |
| 刊名 | Macromolecular chemistry and physics
 |
| 出版日期 | 2009-12-04 |
| 卷号 | 210期号:23页码:2078-2086 |
| 关键词 | Amphiphiles Drug delivery systems Graft copolymers Poly(epsilon-caprolactone) Poly(glycidol) Polymeric micelles |
| ISSN号 | 1022-1352 |
| DOI | 10.1002/macp.200900274 |
| 通讯作者 | Gan, zhihua() |
| 英文摘要 | A series of amphiphilic graft copolymers of poly(ethylene glycol)-co-glycidol-graft-(epsilon-caprolactone) (peg-co-pgl-g-pcl) with peg as the hydrophilic backbone chain and hydrophobic pcl as side chains have been synthesized by living anionic polymerization and ring-opening polymerization. by changing the composition or the reg-co-pgl backbone chains, and the molar ratio of cl monomer to peg-co-pgl in the feed, copolymers with well-defined architecture and controllable numbers and length of graft chains can be obtained. the micellization and drug release of the peg-co-pgl-g-pcl graft copolymers have been studied in terms of dependence on graft numbers and length, and the results indicate that the micelles with shorter pcl side chains have more compact cores and a relatively small size which are favorable for drug loading and controlled release. |
| WOS关键词 | MICELLE FORMATION ; TRIBLOCK COPOLYMER ; GRAFT COPOLYMER ; NANOPARTICLES ; OXIDE) ; CHAINS ; BEHAVIOR ; WATER |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000272756400011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399104 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gan, Zhihua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Jing,Gan, Zhihua. Amphiphilic peg-co-pgl-g-pcl copolymer brushes: synthesis, micellization and controlled drug delivery[J]. Macromolecular chemistry and physics,2009,210(23):2078-2086. |
| APA | Mao, Jing,&Gan, Zhihua.(2009).Amphiphilic peg-co-pgl-g-pcl copolymer brushes: synthesis, micellization and controlled drug delivery.Macromolecular chemistry and physics,210(23),2078-2086. |
| MLA | Mao, Jing,et al."Amphiphilic peg-co-pgl-g-pcl copolymer brushes: synthesis, micellization and controlled drug delivery".Macromolecular chemistry and physics 210.23(2009):2078-2086. |
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来源：中国科学院大学
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