Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics
文献类型：期刊论文
| 作者 | Wei, Youheng1,2,3; Xiao, Qianghai1,2,3; Zhang, Ting1,2; Mou, Zongchun1,2,3; You, Jia1,2,3; Ma, Wei-Jun1,2 |
| 刊名 | Nucleic acids research
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 37期号:19页码:6550-6561 |
| ISSN号 | 0305-1048 |
| DOI | 10.1093/nar/gkp693 |
| 通讯作者 | Ma, wei-jun(wjma@sibs.ac.cn) |
| 英文摘要 | The tight regulation of transiently expressed antimicrobial peptides (amps) with a distinct antimicrobial spectrum and different expression kinetics contributes greatly to the properly regulated immune response for resistance to pathogens and for the maintenance of mutualistic microbiota in drosophila. the important role of differential regulation of amp expression at the posttranscriptional level needs to be elucidated. it was observed that the highly expressed cecropin a1 (ceca1) mrna encoding a broad antimicrobial spectrum amp against both bacteria and fungi decayed more quickly than did the moderately expressed diptericin mrna encoding amp against gram negative bacteria. the mrna stability of amps is differentially regulated and is attributed to the specific interaction between cis-acting are in 30-utr of amp mrna and the rna destabilizing protein transactor tis11 as shown in co-immunoprecipitation of the tis11 rnp complex with ceca1 mrna but not other amp mrna. the p38mapk was further demonstrated to play a crucial role in stabilizing are-bearing mrnas by inhibiting tis11-mediated degradation in lps induced amp expression. this evidence suggests an evolutionarily conserved and functionally important molecular basis for and effective approach to exact control of amp gene expression. these mechanisms thereby orchestrate a well balanced and dynamic antimicrobial spectrum of innate immunity to resist infection and maintain resident microbiota properly. |
| WOS关键词 | AU-RICH ELEMENTS ; KAPPA-B ; BINDING-PROTEINS ; DOWN-REGULATION ; HOST-DEFENSE ; IMD-PATHWAY ; TRISTETRAPROLIN ; INDUCTION ; INFECTION ; KINASE |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000271389900022 |
| 出版者 | OXFORD UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399309 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ma, Wei-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Youheng,Xiao, Qianghai,Zhang, Ting,et al. Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics[J]. Nucleic acids research,2009,37(19):6550-6561. |
| APA | Wei, Youheng,Xiao, Qianghai,Zhang, Ting,Mou, Zongchun,You, Jia,&Ma, Wei-Jun.(2009).Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics.Nucleic acids research,37(19),6550-6561. |
| MLA | Wei, Youheng,et al."Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics".Nucleic acids research 37.19(2009):6550-6561. |
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来源：中国科学院大学
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