The glypican dally is required in the niche for the maintenance of germline stem cells and short-range bmp signaling in the drosophila ovary
文献类型：期刊论文
| 作者 | Guo, Zheng1,2; Wang, Zhaohui1 |
| 刊名 | Development
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 136期号:21页码:3627-3635 |
| 关键词 | Glypican Germline stem cell Niche Bmp Short-range signaling |
| ISSN号 | 0950-1991 |
| DOI | 10.1242/dev.036939 |
| 通讯作者 | Wang, zhaohui(zhwang@genetics.ac.cn) |
| 英文摘要 | The drosophila ovary is an excellent system with which to study germline stem cell (gsc) biology. two or three female gscs are maintained in a structure called a niche at the anterior tip of the ovary. the somatic niche cells surrounding the gscs include terminal filament cells, cap cells and escort stem cells. mounting evidence has demonstrated that bmp-like morphogens are the immediate upstream signals to promote gsc fate by preventing the expression of bam, a key differentiation factor. in contrast to their morphogenic long-range action in imaginal epithelia, bmp molecules in the ovarian niche specify gsc fate at single-cell resolution. how this steep gradient of bmp response is achieved remains elusive. in this study, we found that the glypican dally is essential for maintaining gsc identity. dally is highly expressed in cap cells. cell-specific dally-rnai, mutant clonal analysis and cell-specific rescue of the gsc-loss phenotype suggest that dally acts in the cap cells adjacent to the gscs. we confirmed that dally facilitated bmp signaling in gscs by examining its downstream targets in various dally mutants. conversely, when we overexpressed dally in somatic cells outside the niche, we increased the number of gsc-like cells apparently by expanding the pro-gsc microenvironment. furthermore, in a genetic setting we revealed a bmp-sensitivity distinction between germline and somatic cells, namely that dally is required for short-range bmp signaling in germline but not in somatic cells. we propose that dally ensures high-level bmp signaling in the ovarian niche and thus female gsc determination. |
| WOS关键词 | BAG-OF-MARBLES ; HEPARAN-SULFATE PROTEOGLYCANS ; MORPHOGEN GRADIENT FORMATION ; SELF-RENEWAL ; DPP ; GENE ; DIFFERENTIATION ; TRANSCRIPTION ; EXPRESSION ; DIVISION |
| WOS研究方向 | Developmental Biology |
| WOS类目 | Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000270659400012 |
| 出版者 | COMPANY OF BIOLOGISTS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399444 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhaohui |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Zheng,Wang, Zhaohui. The glypican dally is required in the niche for the maintenance of germline stem cells and short-range bmp signaling in the drosophila ovary[J]. Development,2009,136(21):3627-3635. |
| APA | Guo, Zheng,&Wang, Zhaohui.(2009).The glypican dally is required in the niche for the maintenance of germline stem cells and short-range bmp signaling in the drosophila ovary.Development,136(21),3627-3635. |
| MLA | Guo, Zheng,et al."The glypican dally is required in the niche for the maintenance of germline stem cells and short-range bmp signaling in the drosophila ovary".Development 136.21(2009):3627-3635. |
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来源：中国科学院大学
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