Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic goto-kakizaki rats
文献类型：期刊论文
| 作者 | Hao, Jiejie2,3; Shen, Weili2; Tian, Chuan2,3; Liu, Zhongbo2,3; Ren, Jinmin2; Luo, Cheng2; Long, Jiangang2; Sharman, Edward1; Liu, Jiankang1 |
| 刊名 | Journal of cellular and molecular medicine
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 13期号:4页码:701-711 |
| 关键词 | Alpha-lipoic acid Acetyl-l-carnitine Nicotinamide Biotin Oxidative damage Mitochondrial dysfunction |
| ISSN号 | 1582-1838 |
| DOI | 10.1111/j.1582-4934.2008.00342.x |
| 通讯作者 | Liu, jiankang(j.liu@uci.edu) |
| 英文摘要 | The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. we hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes. in the present study, we investigated this hypothesis in diabetic goto-kakizaki rats by treatment with a combination of four mitochondrial-targeting nutrients, namely, r-alpha-lipoic acid, acetyl-l-carnitine, nicotinamide and biotin. we first studied the effects of the combination of these four nutrients on immune function by examining cell proliferation in immune organs (spleen and thymus) and immunomodulating factors in the plasma. we then examined, in the plasma and thymus, oxidative damage biomarkers, including lipid peroxidation, protein oxidation, reactive oxygen species, calcium and antioxidant defence systems, mitochondrial potential and apoptosis-inducing factors (caspase 3, p53 and p21). we found that immune dysfunction in these animals is associated with increased oxidative damage and mitochondrial dysfunction and that the nutrient treatment effectively elevated immune function, decreased oxidative damage, enhanced mitochondrial function and inhibited the elevation of apoptosis factors. these effects are comparable to, or greater than, those of the anti-diabetic drug pioglitazone. these data suggest that a rational combination of mitochondrial-targeting nutrients may be effective in improving immune function in type 2 diabetes through enhancement of mitochondrial function, decreased oxidative damage, and delayed cell death in the immune organs and blood. |
| WOS关键词 | ALPHA-LIPOIC-ACID ; ACETYL-L-CARNITINE ; AGE-ASSOCIATED MITOCHONDRIAL ; OXIDATIVE STRESS ; OLD RATS ; COGNITIVE DYSFUNCTION ; LIVER-MITOCHONDRIA ; CELLS ; BRAIN ; DECAY |
| WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
| WOS类目 | Cell Biology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000265427300010 |
| 出版者 | WILEY-BLACKWELL PUBLISHING, INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399464 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jiankang |
| 作者单位 | 1.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Jiejie,Shen, Weili,Tian, Chuan,et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic goto-kakizaki rats[J]. Journal of cellular and molecular medicine,2009,13(4):701-711. |
| APA | Hao, Jiejie.,Shen, Weili.,Tian, Chuan.,Liu, Zhongbo.,Ren, Jinmin.,...&Liu, Jiankang.(2009).Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic goto-kakizaki rats.Journal of cellular and molecular medicine,13(4),701-711. |
| MLA | Hao, Jiejie,et al."Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic goto-kakizaki rats".Journal of cellular and molecular medicine 13.4(2009):701-711. |
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来源：中国科学院大学
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