Research progress in anti-diabetic effects of vanadium compounds
文献类型：期刊论文
| 作者 | Wei Dan; Ding Wenjun; Zhou Ju; Peng Duan; Li Ming |
| 刊名 | Progress in chemistry
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 21期号:5页码:896-902 |
| ISSN号 | 1005-281X |
| 关键词 | Vanadium compounds Diabetes mellitus Anti-diabetic effect |
| 通讯作者 | Wei dan() |
| 英文摘要 | It is well known that diabetes mellitus (dm) is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. numerous studies have shown that vanadium and its compounds improve glucose homeostasis and insulin resistance in type i and type u diabetes mellitus. vanadium and its compounds appear to have a profound impact on insulin action through the insulin signaling cascade, but the underlying mechanism is not fully understood. this review summarizes recent work to identify the effects of pharmaceutical treatment of vanadium compounds on insulin signaling and glucose uptake, in an attempt to characterize the molecular mechanism accounting for biological actions and insulin-mimesis of vanadium compounds in dm. |
| WOS关键词 | INDUCED DIABETIC-RATS ; PROTEIN-TYROSINE PHOSPHATASES ; VANADATE NORMALIZES HYPERGLYCEMIA ; INSULIN-MIMETIC ACTIVITY ; IN-VIVO ; GLUCOSE-METABOLISM ; PHOSPHOENOLPYRUVATE CARBOXYKINASE ; PHOSPHATIDYLINOSITOL 3-KINASE ; SKELETAL-MUSCLE ; KKA(Y) MICE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | CHINESE ACAD SCIENCES |
| WOS记录号 | WOS:000266016000012 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399508 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wei Dan |
| 作者单位 | Chinese Acad Sci, Coll Life Sci, Grad Univ, Lab Environm & Hlth, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei Dan,Ding Wenjun,Zhou Ju,et al. Research progress in anti-diabetic effects of vanadium compounds[J]. Progress in chemistry,2009,21(5):896-902. |
| APA | Wei Dan,Ding Wenjun,Zhou Ju,Peng Duan,&Li Ming.(2009).Research progress in anti-diabetic effects of vanadium compounds.Progress in chemistry,21(5),896-902. |
| MLA | Wei Dan,et al."Research progress in anti-diabetic effects of vanadium compounds".Progress in chemistry 21.5(2009):896-902. |
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来源：中国科学院大学
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