Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2
文献类型：期刊论文
| 作者 | Jiao, B.2,3; Wu, C-F2,3; Liang, Y.2,3; Chen, H-M2,3; Xiong, S-M2,3; Chen, B.2,3; Shi, J-Y2,3; Wang, Y-Y2,3; Wang, J-H2,3; Chen, Y.2,3 |
| 刊名 | Leukemia
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 23期号:9页码:1598-1604 |
| 关键词 | Aml1-eto Aml1-eto9a C-kit T(8 Acute myeloid leukemia-m2 21) |
| ISSN号 | 0887-6924 |
| DOI | 10.1038/leu.2009.104 |
| 通讯作者 | Chen, s-j(sjchen@stn.sh.cn) |
| 英文摘要 | Aml1-eto fusion gene is generated from chromosomal translocation t(8;21) mainly in acute myeloid leukemia m2 subtype (aml-m2). its spliced variant transcript, aml1-eto9a, rapidly induces leukemia in murine model. to evaluate its clinical significance, aml1-eto9a expression was assessed in 118 patients with t(8; 21) aml-m2, using qualitative and nested quantitative reverse transcriptase (rt)-pcr methods. these cases were accordingly divided into the aml1-eto9a-h group (n = 86, positive for qualitative rt-pcr, with higher level of aml1-eto9a by quantitative rt-pcr) and the aml1-eto9a-l group (n = 32, negative for qualitative rt-pcr, with lower but still detectable level of aml1-eto9a by quantitative rt-pcr). c-kit expression was significantly increased in the aml1-eto9a-h group, as compared with the aml1-eto9a-l group. of the 36 patients harboring c-kit mutations, 32 patients overexpressed aml1-eto9a (p = 0.0209). clinically, aml1-eto9a-h patients exhibited significantly elevated white blood cells count, less bone marrow aberrant myelocytes, increased cd56 but decreased cd19 expression (p = 0.0451, p = 0.0479, p = 0.0149 and p = 0.0298, respectively). moreover, aml1-eto9a overexpression was related to short event-free and overall survival time (p = 0.0072 and p = 0.0076, respectively). taken together, these data suggest that aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) aml-m2. leukemia (2009) 23, 1598-1604; doi:10.1038/leu.2009.104; published online 21 may 2009 |
| WOS关键词 | RECEPTOR TYROSINE KINASES ; BINDING-FACTOR LEUKEMIAS ; PROGNOSTIC IMPACT ; MUTATIONS ; LEUKEMOGENESIS ; TRANSLOCATION ; AML ; T(8/21)(Q22,Q22) ; DIAGNOSIS ; SURVIVAL |
| WOS研究方向 | Oncology ; Hematology |
| WOS类目 | Oncology ; Hematology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269674200008 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399598 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, S-J |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Med Genom, Shanghai Inst Hematol,Rui Jin Hosp, Shanghai 200025, Peoples R China 2.Chinese Acad Sci, State Key Lab Med Genom, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, B.,Wu, C-F,Liang, Y.,et al. Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2[J]. Leukemia,2009,23(9):1598-1604. |
| APA | Jiao, B..,Wu, C-F.,Liang, Y..,Chen, H-M.,Xiong, S-M.,...&Chen, S-J.(2009).Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2.Leukemia,23(9),1598-1604. |
| MLA | Jiao, B.,et al."Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2".Leukemia 23.9(2009):1598-1604. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。