Effects of keratinocyte growth factor 2(kgf-2) on keratinocyte growth, migration and on excisional wound healing
文献类型：期刊论文
| 作者 | Xia, Chen; Wei, Hu; Wei, Wan-Gui; Yan, Shen; Yan, Chen; Yang, Sheng-Li; Yi, Gong1 |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 36期号:7页码:854-862 |
| 关键词 | Kgf-2 Keratinocyte cell proliferation Cell apoptosis Cell migration Wound healing Therapeutic application |
| ISSN号 | 1000-3282 |
| DOI | 10.3724/sp.j.1206.2008.00724 |
| 通讯作者 | Yi, gong(yigong@srcb.ac.cn) |
| 英文摘要 | Keratinocyte growth factor 2 (kgf-2) is a member of the fgf family that is mainly synthesized by mesenchymal cells and acts predominantly on epithelial cells in a paracrine manner. it is known to play an important role in fetal limb and lung development; skin wound healing and prostatic epithelial cell growth. the kgf-2 coding sequence were isolated from human kidney cdna library, revealing that the kgf-2 gene is also expressed in the kidney apparatus. purified from prokaryotic e. coli cells, the effects of the recombinant kgf-2 protein in cultured keratinocyte were analyzed by using mtt assay and it, situ tunel assay. interestingly, results revealed that kgf-2 promoted keratinocyte cell growth by stimulating cell proliferation and attenuating cell apoptosis. these findings supported a few evidences that kgf-2 could contribute to alveolar epithelial cells against apoptosis. cell migration assays for the first time revealed that kgf-2 could stimulate keratinocyte cell migration in vitro. in addition, in the pilot animal test, recombinant kgf-2 incorporated within the hydrogel dressing exhibited significantly stimulatory effect on cutaneous wound healing. these combined effects implicate a potential therapeutic application of human recombinant kgf-2 in the future. |
| WOS关键词 | WHITE ADIPOSE-TISSUE ; CELL DNA-DAMAGE ; MAPK ACTIVATION ; FACTOR FGF-7 ; EXPRESSION ; PROLIFERATION ; APOPTOSIS ; FGF10 ; MECHANISMS ; SURVIVAL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000268211100009 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2399605 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yi, Gong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Chen,Wei, Hu,Wei, Wan-Gui,et al. Effects of keratinocyte growth factor 2(kgf-2) on keratinocyte growth, migration and on excisional wound healing[J]. Progress in biochemistry and biophysics,2009,36(7):854-862. |
| APA | Xia, Chen.,Wei, Hu.,Wei, Wan-Gui.,Yan, Shen.,Yan, Chen.,...&Yi, Gong.(2009).Effects of keratinocyte growth factor 2(kgf-2) on keratinocyte growth, migration and on excisional wound healing.Progress in biochemistry and biophysics,36(7),854-862. |
| MLA | Xia, Chen,et al."Effects of keratinocyte growth factor 2(kgf-2) on keratinocyte growth, migration and on excisional wound healing".Progress in biochemistry and biophysics 36.7(2009):854-862. |
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来源：中国科学院大学
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