Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zheng, Bo; Liu, Yiquan; Li, Huihui; Ye, Yunhua; Gao, Xingming; Yuan, Gu |
| 刊名 | Journal of mass spectrometry
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 44期号:10页码:1478-1481 |
| 关键词 | Esi mass spectrometry Abundance ratio of ions Cyclic peptide diastereomers Epimer Distinguishing diastereomer |
| ISSN号 | 1076-5174 |
| DOI | 10.1002/jms.1635 |
| 通讯作者 | Yuan, gu(guyuan@pku.edu.cn) |
| 英文摘要 | In this research, the characteristic ions' abundance ratio between two isomers a and b in ms/ms mass spectra was defined as a parameter for discriminating diastereomers. through this ratio, the discrimination of four pairs of cyclic peptide (cp) diastereomers was successfully achieved. furthermore, in the analysis of diastereomers' mixtures, both calibration curve and calculational methods were substantiated to have high precision and accuracy. the average absolute errors of the two methods were 2.0 and 2.5% in the 48 measurements of 16 samples, respectively. this research provided a promising approach for the analysis of the cp diastereomers in the fields of asymmetrical synthesis, chiral natural products and structural biology by esi-ms/ms. copyright (c) 2009 john wiley & sons, ltd. |
| WOS关键词 | DIFFERENTIATION ; ISOMERS ; CYCLIZATION ; PAIRS |
| WOS研究方向 | Biophysics ; Chemistry ; Spectroscopy |
| WOS类目 | Biophysics ; Chemistry, Organic ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000271722500008 |
| 出版者 | JOHN WILEY & SONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2400181 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yuan, Gu |
| 作者单位 | Peking Univ, Coll Chem & Chem Engn, Dept Biol Chem,Beijing Natl Lab Mol Sci, Minist Educ,Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Bo,Liu, Yiquan,Li, Huihui,et al. Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry[J]. Journal of mass spectrometry,2009,44(10):1478-1481. |
| APA | Zheng, Bo,Liu, Yiquan,Li, Huihui,Ye, Yunhua,Gao, Xingming,&Yuan, Gu.(2009).Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry.Journal of mass spectrometry,44(10),1478-1481. |
| MLA | Zheng, Bo,et al."Discrimination of cyclic peptide diastereomers by electrospray ionization tandem mass spectrometry".Journal of mass spectrometry 44.10(2009):1478-1481. |
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来源：中国科学院大学
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