Snap-25(1-180) enhances insulin secretion by blocking kv2.1 channels in rat pancreatic islet beta-cells
文献类型：期刊论文
| 作者 | Zhuang, Guo-qing1; Wu, Wei2; Liu, Fen2; Ma, Jun-li2; Luo, Yan-xia2; Xiao, Zhong-xin2; Liu, Yan2; Wang, Wei1; He, Yan2 |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2009-02-20 |
| 卷号 | 379期号:4页码:812-816 |
| 关键词 | Voltage-gated potassium (k-v) channel Snap-25 Glucose-dependent Insulin |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2008.12.059 |
| 通讯作者 | Wang, wei() |
| 英文摘要 | Voltage-gated outward k+ currents from pancreatic islet beta-cells are known to repolarize the action potential during a glucose stimulus, and consequently to modulate ca2+ entry and insulin secretion. the voltage gated k+ (kv) channel, kv2.1, which is expressed in rat islet beta-cells, mediates over 60% of the kv outward k+ currents. a novel peptidyl inhibitor of kv2.1/kv2.2 channels, guangxitoxin (gxtx)-1, has been shown to enhance glucose-stimulated insulin secretion. here, we show that snap-25(1-180) (s180), an n-terminal snap-25 domain, but not snap-25(1-206) (s206), inhibits kv current and enhances glucose-dependent insulin secretion from rat pancreatic islet beta-cells, and furthermore, this enhancement was induced by the blockade of the kv2.1 current. this study indicates that the kv2.1 channel is a potential target for novel therapeutic agent design for the treatment of type 2 diabetes. this target may possess advantages over currently-used therapies, which modulate insulin secretion in a glucose-independent manner. (c) 2008 published by elsevier inc. |
| WOS关键词 | DEPENDENT K+ CHANNELS ; SYNAPTOSOME-ASSOCIATED PROTEIN ; POTASSIUM PERMEABILITY ; DISTINCT DOMAINS ; GLUCOSE ; DEPOLARIZATION ; MODULATION ; MECHANISMS ; INHIBITOR ; SNARE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000263336700003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2400745 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Capital Med Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth & Family Med, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhuang, Guo-qing,Wu, Wei,Liu, Fen,et al. Snap-25(1-180) enhances insulin secretion by blocking kv2.1 channels in rat pancreatic islet beta-cells[J]. Biochemical and biophysical research communications,2009,379(4):812-816. |
| APA | Zhuang, Guo-qing.,Wu, Wei.,Liu, Fen.,Ma, Jun-li.,Luo, Yan-xia.,...&He, Yan.(2009).Snap-25(1-180) enhances insulin secretion by blocking kv2.1 channels in rat pancreatic islet beta-cells.Biochemical and biophysical research communications,379(4),812-816. |
| MLA | Zhuang, Guo-qing,et al."Snap-25(1-180) enhances insulin secretion by blocking kv2.1 channels in rat pancreatic islet beta-cells".Biochemical and biophysical research communications 379.4(2009):812-816. |
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来源：中国科学院大学
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