Adiponectin deficiency impairs liver regeneration through attenuating stat3 phosphorylation in mice
文献类型：期刊论文
| 作者 | Shu, Run-Zhe4; Zhang, Feng4; Wang, Fang2; Feng, De-Chun4; Li, Xi-Hua2; Ren, Wei-Hua2,3; Wu, Xiao-Lin2; Yang, Xue2; Liao, Xiao-Dong2; Huang, Lei2 |
| 刊名 | Laboratory investigation
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 89期号:9页码:1043-1052 |
| 关键词 | Cell proliferation Hepatic steatosis Knockout mice Partial hepatectomy Socs3 Stat3 Ppar alpha |
| ISSN号 | 0023-6837 |
| DOI | 10.1038/labinvest.2009.63 |
| 通讯作者 | Wang, zhu-gang(zhugangw@shsmu.edu.cn) |
| 英文摘要 | Liver regeneration is a very complex and well-orchestrated process associated with signaling cascades involving cytokines, growth factors, and metabolic pathways. adiponectin is an adipocytokine secreted by mature adipocytes, and its receptors are widely distributed in many tissues, including the liver. adiponectin has direct actions in the liver with prominent roles to improve hepatic insulin sensitivity, increase fatty acid oxidation, and decrease inflammation. to test the hypothesis that adiponectin is required for normal progress of liver regeneration, 2/3 partial hepatectomy (ph) was performed on wild-type and adiponectin-null mice. compared to wild-type mice, adiponectin-null mice displayed decreased liver mass regrowth, impeded hepatocyte proliferation, and increased hepatic lipid accumulation. gene expression analysis revealed that adiponectin regulated the gene transcription related to lipid metabolism. furthermore, the suppressed hepatocyte proliferation was accompanied with reduced signal transducer and activator of transcription protein 3 (stat3) activity and enhanced suppressor of cytokine signaling 3 (socs3) transcription. in conclusion, adiponectin-null mice exhibit impaired liver regeneration and increased hepatic steatosis. increased expression of socs3 and subsequently reduced activation of stat3 in adiponectin-null mice may contribute to the alteration of the liver regeneration capability and hepatic lipid metabolism after ph. laboratory investigation (2009) 89, 1043-1052; doi:10.1038/labinvest.2009.63; published online 29 june 2009 |
| WOS关键词 | PARTIAL-HEPATECTOMY ; PRIMARY NONFUNCTION ; HEPATIC STEATOSIS ; KNOCKOUT MICE ; OBESE MICE ; MOUSE ; ALPHA ; ACID ; EXPRESSION ; PROTEIN |
| WOS研究方向 | Research & Experimental Medicine ; Pathology |
| WOS类目 | Medicine, Research & Experimental ; Pathology |
| 语种 | 英语 |
| WOS记录号 | WOS:000269323600008 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2400753 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhu-Gang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Dept Med Genet,Key Lab Stem Cell Biol,Inst Hlth S, Chinese Acad Sci,Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Dept Med Genet, Shanghai Univ,E Inst, Shanghai 200025, Peoples R China 3.Shanghai Res Ctr Model Organisms, Shanghai, Peoples R China 4.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Run-Zhe,Zhang, Feng,Wang, Fang,et al. Adiponectin deficiency impairs liver regeneration through attenuating stat3 phosphorylation in mice[J]. Laboratory investigation,2009,89(9):1043-1052. |
| APA | Shu, Run-Zhe.,Zhang, Feng.,Wang, Fang.,Feng, De-Chun.,Li, Xi-Hua.,...&Wang, Zhu-Gang.(2009).Adiponectin deficiency impairs liver regeneration through attenuating stat3 phosphorylation in mice.Laboratory investigation,89(9),1043-1052. |
| MLA | Shu, Run-Zhe,et al."Adiponectin deficiency impairs liver regeneration through attenuating stat3 phosphorylation in mice".Laboratory investigation 89.9(2009):1043-1052. |
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来源：中国科学院大学
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