Role of hypoleptinemia during cold adaptation in brandt's voles (lasiopodomys brandtii)
文献类型：期刊论文
| 作者 | Tang, Gang-Bin1,2; Cui, Jian-Guo1,2; Wang, De-Hua1 |
| 刊名 | American journal of physiology-regulatory integrative and comparative physiology
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 297期号:5页码:R1293-r1301 |
| 关键词 | Cold exposure Leptin administration Neuropeptide |
| ISSN号 | 0363-6119 |
| DOI | 10.1152/ajpregu.00185.2009 |
| 通讯作者 | Wang, de-hua(wangdh@ioz.ac.cn) |
| 英文摘要 | Tang g-b, cui j-g, wang d-h. role of hypoleptinemia during cold adaptation in brandt's voles (lasiopodomys brandtii). am j physiol regul integr comp physiol 297: r1293-r1301, 2009. first published september 2, 2009; doi: 10.1152/ajpregu.00185.2009.-brandt's voles lasiopodomys brandtii exhibit large increases in non-shivering thermogenesis to cope with chronic cold exposure, resulting in compensatory hyperphagia and fat mobilization. these physiological events are accompanied by a remarkable reduction in serum leptin levels. however, the role of hypoleptinemia in cold adaptation in this species is still unknown. in the present study, we tested the hypothesis that hypoleptinemia contributes to increases in food intake and brown adipose tissue (bat) thermogenesis by modifying hypothalamic neuropeptides in cold-exposed brandt's voles. adult male voles were transferred to 5 degrees c for 28 days. accompanied by a decrease in serum leptin levels, hypothalamic agouti-related protein (agrp) mrna levels were significantly increased, but there were no changes in the long form of leptin receptor (ob-rb), suppressor of cytokine signaling 3 (socs3), neuropeptide y (npy) mrna, proopiomelanocortin (pomc), and cocaine-and amphetamine-regulated peptide (cart) mrna levels in the hypothalamus. when cold-exposed voles were returned to warm (23 degrees c) for 28 days, body mass, food intake, serum leptin, and agrp mrna were restored to control levels. leptin administration in cold-exposed voles decreased food intake as well as hypothalamic agrp mrna levels. there were no significant effects of leptin administration on hypothalamic ob-rb, socs3, npy, pomc, cart mrna, and uncoupling protein 1 levels under cold conditions. these results suggest that hypoleptinemia partially contributes to cold-induced hyperphagia, which might involve the elevation of hypothalamic agrp gene expression. |
| WOS关键词 | BROWN ADIPOSE-TISSUE ; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ; AMPHETAMINE-REGULATED TRANSCRIPT ; AGOUTI-RELATED PROTEIN ; NEUROPEPTIDE-Y ; GENE-EXPRESSION ; LEPTIN RECEPTOR ; ARCUATE NUCLEUS ; BODY-WEIGHT ; ENERGY-METABOLISM |
| WOS研究方向 | Physiology |
| WOS类目 | Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000271371900009 |
| 出版者 | AMER PHYSIOLOGICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401013 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, De-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Gang-Bin,Cui, Jian-Guo,Wang, De-Hua. Role of hypoleptinemia during cold adaptation in brandt's voles (lasiopodomys brandtii)[J]. American journal of physiology-regulatory integrative and comparative physiology,2009,297(5):R1293-r1301. |
| APA | Tang, Gang-Bin,Cui, Jian-Guo,&Wang, De-Hua.(2009).Role of hypoleptinemia during cold adaptation in brandt's voles (lasiopodomys brandtii).American journal of physiology-regulatory integrative and comparative physiology,297(5),R1293-r1301. |
| MLA | Tang, Gang-Bin,et al."Role of hypoleptinemia during cold adaptation in brandt's voles (lasiopodomys brandtii)".American journal of physiology-regulatory integrative and comparative physiology 297.5(2009):R1293-r1301. |
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来源：中国科学院大学
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