Hyper-excitability in low threshold mechanical a fibers is potentially involved in scorpion bmk sting pain
文献类型：期刊论文
| 作者 | Liu, Ying2; Bai, Zhan-Tao2; Feng, Xing-Hua2; Li, Wen-Peng1; Yang, Hong-Tian1; Zhou, Jing-Jing1; Ji, Yong-Hua1 |
| 刊名 | Brain research bulletin
 |
| 出版日期 | 2009-09-28 |
| 卷号 | 80期号:3页码:116-121 |
| 关键词 | Low threshold mechanical a fiber Bmk i Single fiber recording Burst discharges Bmk scorpion sting pain |
| ISSN号 | 0361-9230 |
| DOI | 10.1016/j.brainresbull.2009.04.007 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | In the present study, using the single fiber recording technique, we found that bmk i, the main toxic component in scorpion buthus martensi karsch (bmk) venom, induced dramatic increase in excitability of rapidly adapting (ra) and type i slowly adapting (sai) low threshold mechanical a fibers of rat. five micrograms bmk 1 (691 nmol, in 10 mu l saline) administrated to the receptive fields induced spontaneous activity in 80% of ra and sai fibers, increased the response to 10 g-10 s stimulation at about 20 times and altered the firing pattern to burst mode with maximal ns (number of spikes in burst) averaging from all fibers studied as many as 59. the increase in the excitability of ra and sai fibers did not recover completely in 2 h. our finding suggests that the gigantic abnormal activity in low threshold mechanical a fibers is involved in bmk scorpion sting pain, and the experimental model of bmk scorpion sting pain can be used to study a-fiber related central pathway which is important for relief of refractory neuropathic pain likewise. (c) 2009 published by elsevier inc. |
| WOS关键词 | DORSAL-ROOT GANGLION ; RAT SPINAL-CORD ; NEUROPATHIC PAIN ; SODIUM-CHANNELS ; NEURONS ; INJURY ; SUPPRESSION ; NEUROTOXIN ; RECEPTOR |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000270259300004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401018 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Lab Neuropharmacol & Neurotoxicol, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ying,Bai, Zhan-Tao,Feng, Xing-Hua,et al. Hyper-excitability in low threshold mechanical a fibers is potentially involved in scorpion bmk sting pain[J]. Brain research bulletin,2009,80(3):116-121. |
| APA | Liu, Ying.,Bai, Zhan-Tao.,Feng, Xing-Hua.,Li, Wen-Peng.,Yang, Hong-Tian.,...&Ji, Yong-Hua.(2009).Hyper-excitability in low threshold mechanical a fibers is potentially involved in scorpion bmk sting pain.Brain research bulletin,80(3),116-121. |
| MLA | Liu, Ying,et al."Hyper-excitability in low threshold mechanical a fibers is potentially involved in scorpion bmk sting pain".Brain research bulletin 80.3(2009):116-121. |
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来源：中国科学院大学
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