Effects of the number and interval of balloon inflations during primary pci on the extent of myocardial injury in patients with stemi: does postconditioning exist in real-world practice?
文献类型：期刊论文
| 作者 | Wang, Guisong2; Zhang, Sanguo3,4; Joggerst, Steven J.; McPherson, John; Zhao, David X.1 |
| 刊名 | Journal of invasive cardiology
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 21期号:9页码:451-455 |
| 关键词 | Myocardial infarction Postconditioning Ischemia reperfusion Cardioprotection |
| ISSN号 | 1042-3931 |
| 通讯作者 | Zhao, david x.() |
| 英文摘要 | Postconditioning reduces infarct size in animal models and clinical studies the present retrospective study aimed to evaluate the effects of the number and interval delay of balloon inflations during primary percutaneous coronary intervention (pci) on enzymatic infarct size myocardial perfusion and cardiac function in patients with st-segment elevation myocardial infarction (stemi) in routine clinical practice methods of the 433 stemi patients who underwent primary pci at vanderbilt university medical center from october 2003 to august 2007, 85 (19 6%) met criteria and were en rolled into two groups those with >= 3 versus with <= 2 balloon inflations peak ck st segment resolution, myocardial blush grade (mbg) and left ventricular (lv) function were compared between the two groups correlations of peak ck mbg and lv ejection fraction (lvef) with the number average duration and the first delay interval of balloon inflations were analyzed a stepwise multiple regression analysis was used to identify the possible determinants of echocardiographic lvef results the lv end-systolic volume (lvesv) index in the group with >= 3 inflations was significantly lower than that with <= 2 inflations (33 1 +/- 7 9 ml/m(2) versus 37 5 +/- 11 2 ml/m(2) p = 0 036) while lvef was significantly higher (50 4 +/- 6 3% versus 46 1 +/- 8 5% p = 0 009) post hoc analysis showed peak ck in patients with 4 inflations was significantly lower than that with <= 2 inflations (1 698 +/- 1 266 iu/l vs 2 603 +/- 1 532 iu/l p < 0 05) there was a positive correlation between lvef and the number of balloon inflations (r = 0 222 p = 0 041) conclusions repetitive balloon inflations during primary po appear to confer cardioprotection the data suggest that postconditioning may exist in real-world practice and contribute to myocardial protection |
| WOS关键词 | PERCUTANEOUS CORONARY INTERVENTION ; PRIMARY ANGIOPLASTY ; INFARCT SIZE ; HUMAN HEART ; REPERFUSION ; RESOLUTION ; MULTIPLE ; BENEFIT ; TERM |
| WOS研究方向 | Cardiovascular System & Cardiology |
| WOS类目 | Cardiac & Cardiovascular Systems |
| 语种 | 英语 |
| WOS记录号 | WOS:000284807000007 |
| 出版者 | H M P COMMUNICATIONS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401064 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, David X. |
| 作者单位 | 1.Vanderbilt Univ, Med Ctr, Cardiac Catheterizat Lab, Div Cardiovasc Med, Nashville, TN 37232 USA 2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China 3.Vanderbilt Univ, Dept Biostat, Sch Med, Nashville, TN 37232 USA 4.Chinese Acad Sci, Sch Math Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Guisong,Zhang, Sanguo,Joggerst, Steven J.,et al. Effects of the number and interval of balloon inflations during primary pci on the extent of myocardial injury in patients with stemi: does postconditioning exist in real-world practice?[J]. Journal of invasive cardiology,2009,21(9):451-455. |
| APA | Wang, Guisong,Zhang, Sanguo,Joggerst, Steven J.,McPherson, John,&Zhao, David X..(2009).Effects of the number and interval of balloon inflations during primary pci on the extent of myocardial injury in patients with stemi: does postconditioning exist in real-world practice?.Journal of invasive cardiology,21(9),451-455. |
| MLA | Wang, Guisong,et al."Effects of the number and interval of balloon inflations during primary pci on the extent of myocardial injury in patients with stemi: does postconditioning exist in real-world practice?".Journal of invasive cardiology 21.9(2009):451-455. |
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来源：中国科学院大学
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