The leaf extract of siberian crabapple (malus baccata (linn.) borkh) contains potential fatty acid synthase inhibitors
文献类型：期刊论文
| 作者 | Wei, Xiang1; Zhao, Ran2; Sun, Ying-Hui3; Cong, Jian-Ping4; Meng, Fan-Guo5; Zhou, Hai-Meng1,5,6 |
| 刊名 | Journal of enzyme inhibition and medicinal chemistry
 |
| 出版日期 | 2009 |
| 卷号 | 24期号:1页码:234-240 |
| 关键词 | Siberian crabapple Leave extract Fatty acid synthase (fas) Inhibitor |
| ISSN号 | 1475-6366 |
| DOI | 10.1080/14756360802051438 |
| 通讯作者 | Wei, xiang(weixiang@mail.tsinghua.edu.cn) |
| 英文摘要 | The present work focused on the kinetics of the inhibitory effects of the leaf extract of siberian crabapple, named shan jingzi in china, on chicken liver fatty acid synthase. the results showed that this extract had much stronger inhibitory ability on fatty acid synthase than that from green teas described in many previous reports. the inhibitory ability of this extract is closely related to the extracting solvent, and the time of extraction was also an important influencing factor. the inhibitory types of this extract on diffeerent substrates of chicken liver fatty acid synthase, acetyl-coa, malonyl-coa and nadph, were found to be noncompetitive, uncompetitive and mixed, respectively. the studies here shed a new light on the exploration for inhibitors of fatty acid synthase. |
| WOS关键词 | TEA EPIGALLOCATECHIN GALLATE ; FOOD-INTAKE ; GREEN TEA ; ENERGY HOMEOSTASIS ; BODY-WEIGHT ; OBESITY ; SIGNALS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000262718700033 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401261 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wei, Xiang |
| 作者单位 | 1.Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China 2.Tsinghua Univ, Dept Phys Educ, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Grad Coll, Dept Biol, Beijing 100049, Peoples R China 4.Shenzhen Univ, Sch Life Sci, Shenzhen 518060, Guangdong, Peoples R China 5.Yangtze Delta Region Inst Tsinghua Univ, Jiaxing 314000, Zhejiang, Peoples R China 6.Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xiang,Zhao, Ran,Sun, Ying-Hui,et al. The leaf extract of siberian crabapple (malus baccata (linn.) borkh) contains potential fatty acid synthase inhibitors[J]. Journal of enzyme inhibition and medicinal chemistry,2009,24(1):234-240. |
| APA | Wei, Xiang,Zhao, Ran,Sun, Ying-Hui,Cong, Jian-Ping,Meng, Fan-Guo,&Zhou, Hai-Meng.(2009).The leaf extract of siberian crabapple (malus baccata (linn.) borkh) contains potential fatty acid synthase inhibitors.Journal of enzyme inhibition and medicinal chemistry,24(1),234-240. |
| MLA | Wei, Xiang,et al."The leaf extract of siberian crabapple (malus baccata (linn.) borkh) contains potential fatty acid synthase inhibitors".Journal of enzyme inhibition and medicinal chemistry 24.1(2009):234-240. |
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来源：中国科学院大学
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