Human basic fibroblast growth factor fused with kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis
文献类型：期刊论文
| 作者 | Zhao, Wenxue1,2; Han, Qianqian1,2; Lin, Hang1,2; Sun, Wenjie1,2; Gao, Yuan1,2; Zhao, Yannan1,2; Wang, Bin1,2; Wang, Xia1,2; Chen, Bing1; Xiao, Zhifeng1 |
| 刊名 | Tissue engineering part a
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 15期号:5页码:991-998 |
| ISSN号 | 1937-3341 |
| DOI | 10.1089/ten.tea.2008.0240 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Appropriate three-dimensional (3d) scaffolds and signal molecules could accelerate tissue regeneration and wound repair. in this work, we targeted human basic fibroblast growth factor (bfgf), a potent angiogenic factor, to a fibrin scaffold to improve therapeutic angiogenesis. we fused bfgf to the kringle4 domain (k4), a fibrin-binding peptide from human plasminogen, to endow bfgf with specific fibrin-binding ability. the recombinant k4bfgf bound specifically to the fibrin scaffold so that k4bfgf was delivered in a site-specific manner, and the fibrin scaffold provided 3d support for cell migration and proliferation. subcutaneous implantation of the fibrin scaffolds bound with k4bfgf but not with bfgf induced neovascularization. immunohistochemical analysis showed significantly more proliferation cells in the fibrin scaffolds incorporated with k4bfgf than in those with bfgf. moreover, the regenerative tissues were integrated well with the fibrin scaffolds, suggesting its good biocompatibility. in summary, targeted delivery of k4bfgf could potentially improve therapeutic angiogenesis. |
| WOS关键词 | THERAPEUTIC ANGIOGENESIS ; HUMAN-PLASMINOGEN ; HINDLIMB ISCHEMIA ; FGF-2 ; INHIBITION ; GENE ; SITE ; VEGF |
| WOS研究方向 | Cell Biology ; Biotechnology & Applied Microbiology |
| WOS类目 | Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | MARY ANN LIEBERT INC |
| WOS记录号 | WOS:000265636600003 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401265 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wenxue,Han, Qianqian,Lin, Hang,et al. Human basic fibroblast growth factor fused with kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis[J]. Tissue engineering part a,2009,15(5):991-998. |
| APA | Zhao, Wenxue.,Han, Qianqian.,Lin, Hang.,Sun, Wenjie.,Gao, Yuan.,...&Dai, Jianwu.(2009).Human basic fibroblast growth factor fused with kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis.Tissue engineering part a,15(5),991-998. |
| MLA | Zhao, Wenxue,et al."Human basic fibroblast growth factor fused with kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis".Tissue engineering part a 15.5(2009):991-998. |
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来源：中国科学院大学
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