O-spiro c-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (sglt2) inhibitors
文献类型：期刊论文
| 作者 | Xu, Baihua1,2,3; Lv, Binhua1,2,3; Feng, Yan2; Xu, Ge2; Du, Jiyan2; Welihinda, Ajith4; Sheng, Zelin2; Seed, Brian4; Chen, Yuanwei1,2 |
| 刊名 | Bioorganic & medicinal chemistry letters
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 19期号:19页码:5632-5635 |
| 关键词 | Sglt Spiro Glucosides |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2009.08.030 |
| 通讯作者 | Xu, baihua(xubaihua2002@163.com) |
| 英文摘要 | Two series of o-spiro c-aryl glucosides were synthesized and tested for inhibition of hsglt1 and hsglt2. 60-o-spiro c-aryl glucosides exhibited potent in vitro hsglt2 inhibitory activity but 20-o-spiro c-aryl glucosides showed no in vitro hsglt2 inhibitory activity at a screening concentration of 1 mu m. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | AFFINITY NA+/GLUCOSE COTRANSPORTER ; HYPERGLYCEMIA ; KIDNEY ; T-1095 |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000270106700024 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401280 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Baihua |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China 2.Egret Pharma Shanghai Ltd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Theracos Inc, Sunnyvale, CA 94085 USA |
| 推荐引用方式 GB/T 7714 | Xu, Baihua,Lv, Binhua,Feng, Yan,et al. O-spiro c-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (sglt2) inhibitors[J]. Bioorganic & medicinal chemistry letters,2009,19(19):5632-5635. |
| APA | Xu, Baihua.,Lv, Binhua.,Feng, Yan.,Xu, Ge.,Du, Jiyan.,...&Chen, Yuanwei.(2009).O-spiro c-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (sglt2) inhibitors.Bioorganic & medicinal chemistry letters,19(19),5632-5635. |
| MLA | Xu, Baihua,et al."O-spiro c-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (sglt2) inhibitors".Bioorganic & medicinal chemistry letters 19.19(2009):5632-5635. |
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来源：中国科学院大学
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