An efficient chiral synthesis of (r)-n-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl]-butanamide with high enantioselectivity
文献类型：期刊论文
| 作者 | Wang NaiXing1,2; Tang XinLiang1,3 |
| 刊名 | Science in china series b-chemistry
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 52期号:8页码:1216-1219 |
| 关键词 | Chiral synthesis Enantioselectivity Enatiomeric excess Chiral hplc analysis |
| ISSN号 | 1006-9291 |
| DOI | 10.1007/s11426-009-0116-x |
| 通讯作者 | Wang naixing(nxwang@mail.ipc.ac.cn) |
| 英文摘要 | R-enantiomer of the beta-receptor antagonist n-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl] butanamide with high enantioselectivity was synthesized from cheap starting materials and enantiopure chiral reagent through an efficient, convenient and practical synthetic strategy. title product was detected by h-1 nmr, c-13 nmr, and ms, and the enatiomeric excess was determined by chiral hplc analysis using a chiracel ad-h column. |
| WOS关键词 | CHEMOENZYMATIC SYNTHESIS ; ACEBUTOLOL ; HYPERTENSION ; PROPRANOLOL ; ENANTIOMERS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000268514800021 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401399 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang NaiXing |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China 3.Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang NaiXing,Tang XinLiang. An efficient chiral synthesis of (r)-n-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl]-butanamide with high enantioselectivity[J]. Science in china series b-chemistry,2009,52(8):1216-1219. |
| APA | Wang NaiXing,&Tang XinLiang.(2009).An efficient chiral synthesis of (r)-n-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl]-butanamide with high enantioselectivity.Science in china series b-chemistry,52(8),1216-1219. |
| MLA | Wang NaiXing,et al."An efficient chiral synthesis of (r)-n-[3-acetyl-4-(2-hydroxy-3-isopropylamino-propoxy)phenyl]-butanamide with high enantioselectivity".Science in china series b-chemistry 52.8(2009):1216-1219. |
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来源：中国科学院大学
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