Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14
文献类型：期刊论文
| 作者 | Ding, Feng2,3; Tang, Petrus4; Hsu, Mei-Hua1; Cui, Peng2,3; Hu, Songnian2; Yu, Jun2; Chiu, Cheng-Hsun1 |
| 刊名 | Bmc genomics
 |
| 出版日期 | 2009-04-13 |
| 卷号 | 10页码:13 |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/1471-2164-10-158 |
| 通讯作者 | Chiu, cheng-hsun(chchiu@adm.cgmh.org.tw) |
| 英文摘要 | Background: streptococcus pneumoniae serotype 14 is one of the most common pneumococcal serotypes that cause invasive pneumococcal diseases worldwide. serotype 14 often expresses resistance to a variety of antimicrobial agents, resulting in difficulties in treatment. to gain insight into the evolution of virulence and antimicrobial resistance traits in s. pneumoniae from the genome level, we sequenced the entire genome of a serotype 14 isolate (cgsp14), and carried out comprehensive comparison with other pneumococcal genomes. multiple serotype 14 clinical isolates were also genotyped by multilocus sequence typing (mlst). results: comparative genomic analysis revealed that the cgsp14 acquired a number of new genes by horizontal gene transfer (hgt), most of which were associated with virulence and antimicrobial resistance and clustered in mobile genetic elements. the most remarkable feature is the acquisition of two conjugative transposons and one resistance island encoding eight resistance genes. results of mlst suggested that the major driving force for the genome evolution is the environmental drug pressure. conclusion: the genome sequence of s. pneumoniae serotype 14 shows a bacterium with rapid adaptations to its lifecycle in human community. these include a versatile genome content, with a wide range of mobile elements, and chromosomal rearrangement; the latter re-balanced the genome after events of hgt. |
| WOS关键词 | INVASIVE PNEUMOCOCCAL DISEASE ; MICROBIAL PAN-GENOME ; NUCLEOTIDE-SEQUENCE ; CONJUGATE VACCINE ; BINDING PROTEINS ; STRAIN R6 ; CHILDREN ; IDENTIFICATION ; GENES ; BIOSYNTHESIS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000266804600001 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401846 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chiu, Cheng-Hsun |
| 作者单位 | 1.Chang Gung Univ, Coll Med, Chang Gung Childrens Hosp, Dept Pediat, Tao Yuan, Taiwan 2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100029, Peoples R China 4.Chang Gung Univ, Coll Med, Dept Parasitol, Tao Yuan, Taiwan |
| 推荐引用方式 GB/T 7714 | Ding, Feng,Tang, Petrus,Hsu, Mei-Hua,et al. Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14[J]. Bmc genomics,2009,10:13. |
| APA | Ding, Feng.,Tang, Petrus.,Hsu, Mei-Hua.,Cui, Peng.,Hu, Songnian.,...&Chiu, Cheng-Hsun.(2009).Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14.Bmc genomics,10,13. |
| MLA | Ding, Feng,et al."Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant streptococcus pneumoniae serotype 14".Bmc genomics 10(2009):13. |
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来源：中国科学院大学
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