Synthesis and controlled drug release of amphiphilic graft copolymers peo-b-pgl-g-pcl
文献类型：期刊论文
| 作者 | Mao Jing1,2; Gan Zhi-Hua1 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 30期号:11页码:2291-2296 |
| 关键词 | Amphiphilic graft copolymer Poly(ethylene oxide) Poly(epsilon-caprolactone) Self-assembly Drug release |
| ISSN号 | 0251-0790 |
| 通讯作者 | Gan zhi-hua(zhgan@iccas.ac.cn) |
| 英文摘要 | Water-soluble diblock copolymers peo-b-pgl with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide (eo) and glycidol (gl). epsilon-caprolactone (cl) was further initiated by the pendant hydroxyl group of each gl unit in peo-b-pgl copolymer to synthesize amphiphilic graft copolymers peo-b-pgl-g-pcl with well defined grafting architecture. the self-assembly behavior of peo-b-pgl-g-pcl graft copolymers was investigated with pyrene as a probe for the determination of critical micelle concentrations (cmc). meanwhile, doxorubicin as a model drug was encapsulated into peo-b-pgl-g-pcl micelles, and its release behavior controlled by diffusion and enzymatic degradation was studied. the influences of composition and grafting structure in peo-b-pgl-g-pcl copolymers on self-assembly, drug loading and release were discussed. |
| WOS关键词 | MICELLES ; MICELLIZATION ; NANOPARTICLES ; DELIVERY ; OXIDE) ; CHAINS ; BLOCK |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000272832200037 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2402239 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gan Zhi-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao Jing,Gan Zhi-Hua. Synthesis and controlled drug release of amphiphilic graft copolymers peo-b-pgl-g-pcl[J]. Chemical journal of chinese universities-chinese,2009,30(11):2291-2296. |
| APA | Mao Jing,&Gan Zhi-Hua.(2009).Synthesis and controlled drug release of amphiphilic graft copolymers peo-b-pgl-g-pcl.Chemical journal of chinese universities-chinese,30(11),2291-2296. |
| MLA | Mao Jing,et al."Synthesis and controlled drug release of amphiphilic graft copolymers peo-b-pgl-g-pcl".Chemical journal of chinese universities-chinese 30.11(2009):2291-2296. |
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来源：中国科学院大学
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