Nmr-based metabonomic study on rat's urinary metabolic response to dosage of triptolide
文献类型：期刊论文
| 作者 | Xia Shengan1,2; Liu Huilang1,2; Zhu Hang1,2; Zhou Zhiming1,2; Zhang Xu1; Liu Maili1 |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 27期号:4页码:751-758 |
| ISSN号 | 1001-604X |
| 关键词 | Nmr Triptolide Principal component analysis Urine |
| 通讯作者 | Liu maili(ml.liu@wipm.ac.cn) |
| 英文摘要 | An nmr-based metabonomic approach was used to examine rat's urinary response to dosage of triptolide (tp), a major component responsible for the immunosuppressive and anti-inflammatory effects of tripterygium wilfordii hook f (twhf). the urine samples of wistar rats were collected at various time intervals before and after dosage of tp (i.p.) and measured using conventional (1)h nmr spectroscopy. the data were statistically analyzed using a principle component analysis (pca). the results showed that biochemical variation induced by tp was time-related, and the maximal alteration in the metabolites appeared at 16 h, and partially recovered 56 it later after dosage. increment in relative concentrations of taurine, creatine, trimethylamine n-oxide and decrement in citrate, succinate, 2-oxoglutarate and hippurate were observed in the urine after dosage of tp. in addition, 2'-deoxycytidine appeared 0-16 h later after the dosage, which may be considered as another biomarker for the acute hepatotoxicity. it suggested that tp may disturb the metabolism of energy and gut microflora, and may cause acute liver lesion and a slight renal impair. these results were also supported by the conventional analysis of clinical plasma chemistry and histopathology. the information observed in this article may be useful for giving insight into mechanism of liver injury induced by tp. |
| WOS关键词 | COLLAGEN-INDUCED ARTHRITIS ; PATTERN-RECOGNITION ; TRIPTERYGIUM-WILFORDII ; MAGNETIC-RESONANCE ; TOXICITY ; H-1-NMR ; EXCRETION ; DISEASE ; CLASSIFICATION ; HEPATOTOXICITY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000265717900024 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2402287 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu Maili |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia Shengan,Liu Huilang,Zhu Hang,et al. Nmr-based metabonomic study on rat's urinary metabolic response to dosage of triptolide[J]. Chinese journal of chemistry,2009,27(4):751-758. |
| APA | Xia Shengan,Liu Huilang,Zhu Hang,Zhou Zhiming,Zhang Xu,&Liu Maili.(2009).Nmr-based metabonomic study on rat's urinary metabolic response to dosage of triptolide.Chinese journal of chemistry,27(4),751-758. |
| MLA | Xia Shengan,et al."Nmr-based metabonomic study on rat's urinary metabolic response to dosage of triptolide".Chinese journal of chemistry 27.4(2009):751-758. |
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来源：中国科学院大学
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