Cxcl14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice
文献类型：期刊论文
| 作者 | Kuang, Haibin1,2,3; Chen, Qi1,2; Fan, Xiujun1,2; Zhang, Ying1,2; Zhang, Li1,2; Peng, Hongying1; Cao, Yujing1; Duan, Enkui1 |
| 刊名 | Journal of cellular physiology
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 221期号:2页码:448-457 |
| ISSN号 | 0021-9541 |
| DOI | 10.1002/jcp.21877 |
| 通讯作者 | Duan, enkui(duane@ioz.ac.cn) |
| 英文摘要 | Cxcl14, a member of chemokine family, was previously known to participate in many pathophysiological events, such as leukocytes recruitment and tumor suppression, however, it remained largely unknown whether cxcl14 is a physiological player during early pregnancy. in this regard, our recent global gene microarray analysis has observed an implantation-specific expression profile of cxcl14 mrna during early pregnancy in mice, showing its higher levels at implantation sites compared to inter-implantation sites, implicating a potential role of cxcl14 in the periimplantation events. in the present investigation, using northern blot, in situ hybridization and immunostaining, we further demonstrated that uterine cxcl14 expression was specifically induced at embryo implantation site and expanded with subsequent decidualization process in a spatiotemporal manner. the implanting embryo also showed a highlighted expression of cxcl14 in the blastocyst trophectoderm and its derived ectoplacental cones (epcs) during postimplantation development. in vitro functional study revealed that cxcl14 could significantly inhibit both primary and secondary trophoblast attachment and outgrowth, correlated with a stage-dependant downregulation of mmp-2 and/or mmp-9 activity. moreover, it was found that biotinylated cxcl14 could specifically bind to trophoblast cells in vitro and in vivo, suggesting trophoblast cell, perhaps expressing the unidentified cxcl14 receptor, is a bioactive target of cxcl14. collectively, our findings provide evidences supporting the contention that cxcl14 is an important paracrine/autocrine modulator regulating trophoblast outgrowth at the maternal-fetal interface during the process of pregnancy establishment. this study is clinically related since cxcl14 is also highly expressed in human receptive endometrium and trophoblasts. j. cell. physiol. 22 1: 448-457, 2009. (c) 2009 wiley-liss, inc. |
| WOS关键词 | EMBRYO IMPLANTATION ; DENDRITIC CELLS ; IN-VIVO ; CHEMOKINE CXCL14 ; TUMOR-GROWTH ; NK CELLS ; EXPRESSION ; BRAK ; CANCER ; TISSUE |
| WOS研究方向 | Cell Biology ; Physiology |
| WOS类目 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000270438300023 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2402392 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Duan, Enkui |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Nanchang Univ, Sch Med, Dept Physiol, Nanchang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Haibin,Chen, Qi,Fan, Xiujun,et al. Cxcl14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice[J]. Journal of cellular physiology,2009,221(2):448-457. |
| APA | Kuang, Haibin.,Chen, Qi.,Fan, Xiujun.,Zhang, Ying.,Zhang, Li.,...&Duan, Enkui.(2009).Cxcl14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice.Journal of cellular physiology,221(2),448-457. |
| MLA | Kuang, Haibin,et al."Cxcl14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice".Journal of cellular physiology 221.2(2009):448-457. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。