Preparation of key intermediates of adrenergic receptor agonists: highly enantioselective production of (r)-alpha-halohydrins with saccharomyces cerevisiae cgmcc 2.396
文献类型：期刊论文
| 作者 | Lin, Hui1,2; Chen, Yong-Zheng1; Xu, Xiao-Ying1; Xiaa, Shi-Wen1; Wang, Li-Xin1 |
| 刊名 | Journal of molecular catalysis b-enzymatic
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 57期号:1-4页码:1-5 |
| 关键词 | Enantioselective reduction Saccharomyces cerevisiae cgmcc 2.396 (r)-alpha-halohydrins Acetophenone derivatives |
| ISSN号 | 1381-1177 |
| DOI | 10.1016/j.molcatb.2008.06.003 |
| 通讯作者 | Xiaa, shi-wen(shiwenxia@yahoo.cn) |
| 英文摘要 | In our effort to screen for strains producing carbonyl reductases with high activity and enantioselectivity, saccharomyces cerevisiae cgmcc 2.396 was found to be able to catalyze the biotransformation of a series of alpha-haloacetophenones to prelog's configurated alcohols in excellent optical purity (> 99% ee). the optimal reaction condition was obtained after the investigation of various crucial factors. under the optimal condition, the product was obtained with high yield (97%) and excellent enantioselectivity (> 99% ee). the usefulness of this strain has been further demonstrated by the synthesis of several (r)-alpha-halohydrins (> 99% ee) of pharmaceutical importance. (c) 2008 elsevier b.v. all rights reserved. |
| WOS关键词 | ALPHA-HALO KETONES ; ASYMMETRIC REDUCTION ; GEOTRICHUM-CANDIDUM ; CHIRAL ALCOHOLS ; PHENYLACETALDEHYDE REDUCTASE ; PRACTICAL SYNTHESIS ; EPOXIDE HYDROLASES ; SOLANUM-TUBEROSUM ; OXIDE DERIVATIVES ; BUILDING-BLOCKS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000264899000001 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2402791 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiaa, Shi-Wen |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Hui,Chen, Yong-Zheng,Xu, Xiao-Ying,et al. Preparation of key intermediates of adrenergic receptor agonists: highly enantioselective production of (r)-alpha-halohydrins with saccharomyces cerevisiae cgmcc 2.396[J]. Journal of molecular catalysis b-enzymatic,2009,57(1-4):1-5. |
| APA | Lin, Hui,Chen, Yong-Zheng,Xu, Xiao-Ying,Xiaa, Shi-Wen,&Wang, Li-Xin.(2009).Preparation of key intermediates of adrenergic receptor agonists: highly enantioselective production of (r)-alpha-halohydrins with saccharomyces cerevisiae cgmcc 2.396.Journal of molecular catalysis b-enzymatic,57(1-4),1-5. |
| MLA | Lin, Hui,et al."Preparation of key intermediates of adrenergic receptor agonists: highly enantioselective production of (r)-alpha-halohydrins with saccharomyces cerevisiae cgmcc 2.396".Journal of molecular catalysis b-enzymatic 57.1-4(2009):1-5. |
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来源：中国科学院大学
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