A discovery of novel micrornas in the silkworm (bombyx mori) genome
文献类型：期刊论文
| 作者 | Yu, Xiaomin1; Zhou, Qing1,2; Cai, Yimei1,2; Luo, Qibin1,3; Lin, Hongbin1; Hu, Songnian1; Yu, Jun1 |
| 刊名 | Genomics
 |
| 出版日期 | 2009-12-01 |
| 卷号 | 94期号:6页码:438-444 |
| 关键词 | Silkworm Micrornas Origin Cluster Targets |
| ISSN号 | 0888-7543 |
| DOI | 10.1016/j.ygeno.2009.08.007 |
| 通讯作者 | Hu, songnian(husn@big.ac.cn) |
| 英文摘要 | Micrornas (mirnas) are pivotal regulators involved in various physiological and pathological processes via their post-transcriptional regulation of gene expressions. we sequenced 14 libraries of small rnas constructed from samples spanning the life cycle of silkworms, and discovered 50 novel mirnas previously not known in animals and verified 43 of them using stem-loop rt-pcr. our genome-wide analyses of 27 species-specific mirnas suggest they arise from transposable elements, protein-coding genes duplication/ transposition and random foldback sequences; which is consistent with the idea that novel animal mirnas may evolve from incomplete self-complementary transcripts and become fixed in the process of co-adaptation with their targets. computational prediction suggests that the silkworm-specific mirnas may have a preference of regulating genes that are related to life-cycle-associated traits, and these genes can serve as potential targets for subsequent studies of the modulating networks in the development of bombyx mori. (c) 2009 elsevier inc. all rights reserved. |
| WOS关键词 | CAENORHABDITIS-ELEGANS ; ARABIDOPSIS-THALIANA ; TRANSPOSABLE ELEMENTS ; DROSOPHILA MICRORNAS ; REGULATORY ROLES ; EVOLUTION ; GENES ; EXPRESSION ; RNAS ; IDENTIFICATION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000272103600010 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2402860 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hu, Songnian |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Genome Informat & Sci, Beijing Inst Genom, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Tech Univ Munich, Dept Genome Oriented Bioinformat, Wissensch Zentrum, D-85350 Freising Weihenstephan, Germany |
| 推荐引用方式 GB/T 7714 | Yu, Xiaomin,Zhou, Qing,Cai, Yimei,et al. A discovery of novel micrornas in the silkworm (bombyx mori) genome[J]. Genomics,2009,94(6):438-444. |
| APA | Yu, Xiaomin.,Zhou, Qing.,Cai, Yimei.,Luo, Qibin.,Lin, Hongbin.,...&Yu, Jun.(2009).A discovery of novel micrornas in the silkworm (bombyx mori) genome.Genomics,94(6),438-444. |
| MLA | Yu, Xiaomin,et al."A discovery of novel micrornas in the silkworm (bombyx mori) genome".Genomics 94.6(2009):438-444. |
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来源：中国科学院大学
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