Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens
文献类型：期刊论文
| 作者 | Zheng, Qi3,5; Zhang, Yong1,2; Chen, Ying1,2; Yang, Ning4; Wang, Xiu-Jie3; Zhu, Dahai1,2 |
| 刊名 | Bmc genomics
 |
| 出版日期 | 2009-02-22 |
| 卷号 | 10页码:13 |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/1471-2164-10-87 |
| 通讯作者 | Zhu, dahai(dhzhu@pumc.edu.cn) |
| 英文摘要 | Background: the genetic closeness and divergent muscle growth rates of broilers and layers make them great models for myogenesis study. in order to discover the molecular mechanisms determining the divergent muscle growth rates and muscle mass control in different chicken lines, we systematically identified differentially expressed genes between broiler and layer skeletal muscle cells during different developmental stages by microarray hybridization experiment. results: taken together, 543 differentially expressed genes were identified between broilers and layers across different developmental stages. we found that differential regulation of slow-type muscle gene expression, satellite cell proliferation and differentiation, protein degradation rate and genes in some metabolic pathways could give great contributions to the divergent muscle growth rates of the two chicken lines. interestingly, the expression profiles of a few differentially expressed genes were positively or negatively correlated with the growth rates of broilers and layers, indicating that those genes may function in regulating muscle growth during development. conclusion: the multiple muscle cell growth regulatory processes identified by our study implied that complicated molecular networks involved in the regulation of chicken muscle growth. these findings will not only offer genetic information for identifying candidate genes for chicken breeding, but also provide new clues for deciphering mechanisms underlining muscle development in vertebrates. |
| WOS关键词 | QUANTITATIVE TRAIT LOCI ; DOWN-REGULATION ; CANCER CELLS ; FOOD-INTAKE ; EXPRESSION ; BODY ; METABOLISM ; NUMBER ; STRAIN ; KEGG |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000264981700001 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2403137 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Dahai |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100021, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing, Peoples R China 4.China Agr Univ, Coll Anim Sci & Technol, Dept Anim Genet & Breeding, Beijing 100094, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Qi,Zhang, Yong,Chen, Ying,et al. Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens[J]. Bmc genomics,2009,10:13. |
| APA | Zheng, Qi,Zhang, Yong,Chen, Ying,Yang, Ning,Wang, Xiu-Jie,&Zhu, Dahai.(2009).Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens.Bmc genomics,10,13. |
| MLA | Zheng, Qi,et al."Systematic identification of genes involved in divergent skeletal muscle growth rates of broiler and layer chickens".Bmc genomics 10(2009):13. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。