Caenorhabditis elegans protein arginine methyltransferase prmt-5 negatively regulates dna damage-induced apoptosis
文献类型：期刊论文
| 作者 | Yang, Mei1,2; Sun, Jianwei1,2; Sun, Xiaojuan1,2; Shen, Qinfang1,2; Gao, Zhiyang1; Yang, Chonglin1 |
| 刊名 | Plos genetics
 |
| 出版日期 | 2009-06-01 |
| 卷号 | 5期号:6页码:14 |
| ISSN号 | 1553-7390 |
| DOI | 10.1371/journal.pgen.1000514 |
| 通讯作者 | Yang, mei() |
| 英文摘要 | Arginine methylation of histone and non-histone proteins is involved in transcription regulation and many other cellular processes. nevertheless, whether such protein modification plays a regulatory role during apoptosis remains largely unknown. here we report that the caenorhabditis elegans homolog of mammalian type ii arginine methyltransferase prmt5 negatively regulates dna damage-induced apoptosis. we show that inactivation of c. elegans prmt-5 leads to excessive apoptosis in germline following ionizing irradiation, which is due to a cep-1/p53-dependent up-regulation of the cell death initiator egl-1. moreover, we provide evidence that cbp-1, the worm ortholog of human p300/cbp, functions as a cofactor of cep-1. prmt-5 forms a complex with both cep-1 and cbp-1 and can methylate the latter. importantly, down-regulation of cbp-1 significantly suppresses dna damage-induced egl-1 expression and apoptosis in prmt-5 mutant worms. these findings suggest that prmt-5 likely represses cep-1 transcriptional activity through cbp-1, which represents a novel regulatory mechanism of p53-dependent apoptosis. |
| WOS关键词 | C-ELEGANS ; CHECKPOINT PROTEIN ; P53 RESPONSE ; METHYLATION ; ACTIVATION ; PATHWAYS ; DIFFERENTIATION ; IDENTIFICATION ; TRANSCRIPTION ; MECHANISMS |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000268444600030 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2403588 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Mei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Mei,Sun, Jianwei,Sun, Xiaojuan,et al. Caenorhabditis elegans protein arginine methyltransferase prmt-5 negatively regulates dna damage-induced apoptosis[J]. Plos genetics,2009,5(6):14. |
| APA | Yang, Mei,Sun, Jianwei,Sun, Xiaojuan,Shen, Qinfang,Gao, Zhiyang,&Yang, Chonglin.(2009).Caenorhabditis elegans protein arginine methyltransferase prmt-5 negatively regulates dna damage-induced apoptosis.Plos genetics,5(6),14. |
| MLA | Yang, Mei,et al."Caenorhabditis elegans protein arginine methyltransferase prmt-5 negatively regulates dna damage-induced apoptosis".Plos genetics 5.6(2009):14. |
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来源：中国科学院大学
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