Bioinformatic analysis of microrna biogenesis and function related proteins in eleven animal genomes
文献类型：期刊论文
| 作者 | Liu, Xiuying4; Luo, GuanZheng2,3; Bai, Xiujuan1; Wang, Xiu-Jie2 |
| 刊名 | Journal of genetics and genomics
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 36期号:10页码:591-601 |
| 关键词 | Microrna Drosha Dicer Argonaute Exportin 5 |
| ISSN号 | 1673-8527 |
| DOI | 10.1016/s1673-8527(08)60151-4 |
| 通讯作者 | Bai, xiujuan(bxj630306@163.com) |
| 英文摘要 | Micrornas are similar to 22 nt long small non-coding rnas that play important regulatory roles in eukaryotes. the biogenesis and functional processes of micrornas require the participation of many proteins, of which, the well studied ones are dicer, drosha, argonaute and exportin 5. to systematically study these four protein families, we screened 11 animal genomes to search for genes encoding above mentioned proteins, and identified some new members for each family. domain analysis results revealed that most proteins within the same family share identical or similar domains. alternative spliced transcript variants were found for some proteins. we also examined the expression patterns of these proteins in different human tissues and identified other proteins that could potentially interact with these proteins. these findings provided systematic information on the four key proteins involved in microrna biogenesis and functional pathways in animals, and will shed light on further functional studies of these proteins. |
| WOS关键词 | NUCLEAR EXPORT ; SMALL RNAS ; C-ELEGANS ; COMPLEX ; FAMILY ; INTERFERENCE ; ARGONAUTE ; PRECURSORS ; EXPRESSION ; DICER |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000271280900002 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2404089 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Bai, Xiujuan |
| 作者单位 | 1.NE Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China 4.NE Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiuying,Luo, GuanZheng,Bai, Xiujuan,et al. Bioinformatic analysis of microrna biogenesis and function related proteins in eleven animal genomes[J]. Journal of genetics and genomics,2009,36(10):591-601. |
| APA | Liu, Xiuying,Luo, GuanZheng,Bai, Xiujuan,&Wang, Xiu-Jie.(2009).Bioinformatic analysis of microrna biogenesis and function related proteins in eleven animal genomes.Journal of genetics and genomics,36(10),591-601. |
| MLA | Liu, Xiuying,et al."Bioinformatic analysis of microrna biogenesis and function related proteins in eleven animal genomes".Journal of genetics and genomics 36.10(2009):591-601. |
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来源：中国科学院大学
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